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- OSELTAMIVIR MOA
- NEURAMINIDASE INHIBITOR
PREVENTS RELEASE/SPREAD OF VIRUS
NORMALLY NEURAMINIDASE: INHIBITS RESP SECRETION, CLEAVES SIALIC ACID SO VIRUS CANNOT BE CLEAVED... CATALYZES VIRUS RELEASE FROM INFECTED CELLS
- ACYCLOVIR MOA
- DNA CHAIN TERMINATION
INCORPORATES TO VIRAL DNA - HAS ONLY 1 HYDROXYL GROUP, SO NEXT BASE CAN'T ATTACH
- ENFUVIRTIDE MOA
- HIV FUSION INHIBITOR
BIND GLYCOPROTEIN 41
BLOCK FUSION OF VIRUS AND HOST CELL MEMBRANE
- EFAVIRENZ MOA
- NNRTI
DIRECTLY BINDS AND INHIBITS REVERSE TRANSCRIPTASE
NO REQUIRE ACTIVATION/INTEGRATION INTO VIRAL DNA LIKE NRTI
- HIV PROTEASE INHIBITOR AE
- LIPODYSTROPHY (FAT ACCUMULATION)
INSULIN RESISTANCE/DIABETES
HYPERLIPIDEMIA
INCREASED LIVER FXN TEST
*INHIB P450*
- PREFERRED RX HIV
- NNRTI + 2 NRTI *CONTRA PREG*
(EFAVIRENZ + LAMI + ZIDO)
PI + 2 NRTI
(LOPINAVIR/RITONAVIR + LAMI+ ZIDO)
- RX SYPHILIS
- PENECILLIN, TETRACYCLINE
- METHICILLIN, NAFCILLIN, OXACILLIN CLASSIFICATION
- anti-STAPHylococcal PENECILLIN
- CLAVULANATE, SULBACTAM, TAZOBACTAM MOA
- BETA LACTAMASE INHIBITOR
PROTECTS PENECILLIN FROM BETA LACTAMASE
NO ANTIMICROBIAL ACTIVITY BY ITSELF
- PROBENECID EFFECT ON PEN EXCRETION
- COMPETITIVE INHIBITOR OF RENAL TUBULAR EXCRETION OF PENECILLIN - INCREASES T1/2
- DOC LISTERIA
- AMPICILLIN +/- SULBACTAM
i need a LIST of AMPs
- 1st generation parental cephalosporin
- cefazolin
- 2nd generation parental cephalosporin
- cefotetan
- 3rd generation parental cephalosporin
- ceftriaxone
- 4th generation parental cephalosporin
- cefepime
- 2ND GENERATION CEPHALOSPORIN USE
- "THE TITAN IS FURIOUS FOR GETTING PROZAC"
CEFOTETAN, CEFUROXIME, CEFPROZIL
URI
MIXED AEROBE/ANAEROBE INFEC
OTITIS MEDIA
SINUSITIS
G+/G-
H. influenza
E. aerogenes
Neisseria
Proteus mirabilis
E.Coli
Klebsiella pneumoniae
Serratia marcenes
- ANTIPSEUDOMONAL CEPHALOSPORIN
- CEFTAZIDIME - 3RD GEN, PARENTAL
"GIVE TAZ A DIME TO EAT PSEUDOMONAS"
- FOSFOMYCIN USE
- G- ENTERO
ACUTE UNCOMPLICATED UTI
CYSTITIS
1 SINGLE 3G DOSE
- VANCOMYCIN ANTIMICROBIAL SPECTRUM
- MRSA, M SENSITIVE, PENECILLIN RESISTANT STREP/ENTERO
G+/G-
C. DIFF PSEUDOMEMBRANOUS COLITIS
- MUPROCIN USE
- IMPETIGO
INFECTED SKIN LESIONS
NASAL COLONIZATION MRSA
G+ COCCI
TOPICAL
- MUPROCIN MOA
- INHIBIT TRNA FORMATION
COMPETE WITH ISOLEUCINE FOR ISOLEUCINE TRNA SYNTHETASE
- DOC RICKETTSIA INFECTION
- TETRACYCLINE
- TETRACYCLINE AE
- TEETH DISCOLORATION
ENAMEL HYPOPLASIA
PHOTODERMATITIS
BONE GROWTH PROB
- MACROLIDE MOA
- ERYTHROMYCIN, CLAIRITHROMYCIN, AZITHROMYCIN
BLOCK PEPTIDYL TRANSFERASE - BLOCK TRANSLOCATION/INHIBIT PROTEIN SYNTHESIS
IRREVERSIBLY BIND 50S RIBOSOME @ 23SRRNA SUBUNIT
- ERYTHROMYCIN DRUG INTERACTION
- INHIBIT P450
INCREASE [] THEOPHYLLINE (COPD)
WARFARIN
CARBAMAZEPINE (CNS TOX, SEVERE ATAXIA)
LOVASTATIN (MYOPATHY, RHABDOMYOLYSIS)
- STREPTOMYCIN USE
- PLAGUE, TULAREMIA, RESISTANT TB
- CLINDAMYCIN USE
- ANAEROBIC INFECTIONS ABOVE DIAPHRAGM - C. PROFRINGENS, B. FRAGILIS
NECROTIZING FASCIITIS WITH PENECILLIN
- CLINDAMYCIN AE
- C. DIFF PSEUDOMEMBRANOUS COLITIS, FEVER, DIARRHEA, COLITIS
- AMINOGLYCOSIDE AE
- TOBRAMYCIN, STREPTOMYCIN, GENTAMYCIN
NEPHROTOXICITY (ESP WITH CEPHALOSPORIN)
OTOTOXICITY (ESP WITH LOOP DIURETIC)
CN VIII
DELAYED -> PERM
- SULFONAMIDE MOA
- INHIBIT FOLATE SYNTHASE
- TRIMETHOPRIM MOA
- INHIBIT DIHYDROFOLATE REDUCTASE
DECREASE PURINE, PYRIMIDINE, AA SYNTHESIS
- SULFONAMIDE/TRIMETOPRIM USE
- PNEUMONIA - P JIROVECI, NOCARDIA
- SULFONAMIDE AE
- CRYSTALLURIA (NEPHROTOXICITY)
HYPERSENSITIVITY (RASH, ANGIOEDEMA)
STEVEN JOHNSON SYNDROME - ERYTHEMA MULTIFORME
HEMOLYTIC ANEMIA (G6PD DEF)
MACROCYTIC ANEMIA (FOLATE DEF)
DISPLACES OTHER DRUGS FROM ALBUMIN (WARFARIN)
- FLUOROQUINOLONE MOA
- INHIBIT DNA GYRASE (G-)
ATTACHES TO A SITE
INHIBIT TYPE IV TOPOISOMERASE (G+)
- FLUOROQUINOLONE RESISTANCE MOA
- BACT RESISTANCE TO A SITE - DNA GYRASE
DECREASE # PORIN IN OUTER MEMBRANE, INHIBIT TOPOISOMERASE ACCESS TO CELL
- FLUOROQUINOLONE AE
- ARTHROPATHY
TENDINOPATHY
CNS EXCITATION - INSOMNIA, SEIZURES
AVOID KIDS
- DAPTOMYCIN USE
- MRSA, VRE, VRS
SKIN INFECTION
SOFT TISSUE INFECTION
DIABETIC FOOT INFECTIONS
BURNS
- ISONIAZID MOA
- ACTIVATED BY CATALASE PEROXIDASE
INHIBIT MYCOLIC ACID SYNTHESIS
- ISONIAZID RESISTANCE MOA
- MUTATION CATALASE PEROXIDASE (KATg GENE)
- ISONIAZID AE
- HYPERSENSITIVITY
PYRIDOXINE DEF PERIPHERAL NEUROPATHY
OPTIC NEUROPATHY
AGE DEPENDENT HEPATITIS
SEIZURE
G6PD DEF HEMATOLOGIC TOX
- WHAT DO YOU GIVE TO PREVENT NEUROTOXICITY WITH ISONIAZID
- B6
- WHO HAS MORE AE IN ISONIAZID PT
- SLOW ACETYLATOR
- RIFAMPIN MOA
- INHIBIT RNAP
INHIBIT INITIATION STEP OF RNA SYNTHESIS
- RIFAMPIN RESISTANCE MOA
- DECREASE AFFINITY RNAP
DECREASE PERMEABILITY
MUTATION IN BACTERIAL DNA DEPENDENT RNAP FOR DRUG
- RIFAMPIN AE
- HYPERSENSITIVITY
HEPATITIS
RED-ORANGE DISCOLORATION TEARS, SALIVA, URINE
- PYRAZINAMIDE AE
- HYPERURICEMIA
GOUT
RASH
JOINT ACHE
HEPATITIS
HEMATOLOGIC EFFECTS
- ETHAMBUTIDE AE
- IMPAIRED COLOR VISION
DOSE DEPENDENT OPTIC NEURITIS
- ETHAMBUTIDE AE
- IMPAIRED COLOR VISION
DOSE DEPENDENT OPTIC NEURITIS
