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Glossary of ex 3

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OSELTAMIVIR MOA
NEURAMINIDASE INHIBITOR

PREVENTS RELEASE/SPREAD OF VIRUS

NORMALLY NEURAMINIDASE: INHIBITS RESP SECRETION, CLEAVES SIALIC ACID SO VIRUS CANNOT BE CLEAVED... CATALYZES VIRUS RELEASE FROM INFECTED CELLS
ACYCLOVIR MOA
DNA CHAIN TERMINATION

INCORPORATES TO VIRAL DNA - HAS ONLY 1 HYDROXYL GROUP, SO NEXT BASE CAN'T ATTACH
ENFUVIRTIDE MOA
HIV FUSION INHIBITOR

BIND GLYCOPROTEIN 41

BLOCK FUSION OF VIRUS AND HOST CELL MEMBRANE
EFAVIRENZ MOA
NNRTI

DIRECTLY BINDS AND INHIBITS REVERSE TRANSCRIPTASE

NO REQUIRE ACTIVATION/INTEGRATION INTO VIRAL DNA LIKE NRTI
HIV PROTEASE INHIBITOR AE
LIPODYSTROPHY (FAT ACCUMULATION)

INSULIN RESISTANCE/DIABETES

HYPERLIPIDEMIA

INCREASED LIVER FXN TEST

*INHIB P450*
PREFERRED RX HIV
NNRTI + 2 NRTI *CONTRA PREG*
(EFAVIRENZ + LAMI + ZIDO)

PI + 2 NRTI
(LOPINAVIR/RITONAVIR + LAMI+ ZIDO)
RX SYPHILIS
PENECILLIN, TETRACYCLINE
METHICILLIN, NAFCILLIN, OXACILLIN CLASSIFICATION
anti-STAPHylococcal PENECILLIN
CLAVULANATE, SULBACTAM, TAZOBACTAM MOA
BETA LACTAMASE INHIBITOR

PROTECTS PENECILLIN FROM BETA LACTAMASE

NO ANTIMICROBIAL ACTIVITY BY ITSELF
PROBENECID EFFECT ON PEN EXCRETION
COMPETITIVE INHIBITOR OF RENAL TUBULAR EXCRETION OF PENECILLIN - INCREASES T1/2
DOC LISTERIA
AMPICILLIN +/- SULBACTAM

i need a LIST of AMPs
1st generation parental cephalosporin
cefazolin
2nd generation parental cephalosporin
cefotetan
3rd generation parental cephalosporin
ceftriaxone
4th generation parental cephalosporin
cefepime
2ND GENERATION CEPHALOSPORIN USE
"THE TITAN IS FURIOUS FOR GETTING PROZAC"

CEFOTETAN, CEFUROXIME, CEFPROZIL

URI
MIXED AEROBE/ANAEROBE INFEC
OTITIS MEDIA
SINUSITIS
G+/G-

H. influenza
E. aerogenes
Neisseria

Proteus mirabilis
E.Coli
Klebsiella pneumoniae
Serratia marcenes
ANTIPSEUDOMONAL CEPHALOSPORIN
CEFTAZIDIME - 3RD GEN, PARENTAL

"GIVE TAZ A DIME TO EAT PSEUDOMONAS"
FOSFOMYCIN USE
G- ENTERO

ACUTE UNCOMPLICATED UTI
CYSTITIS

1 SINGLE 3G DOSE
VANCOMYCIN ANTIMICROBIAL SPECTRUM
MRSA, M SENSITIVE, PENECILLIN RESISTANT STREP/ENTERO

G+/G-

C. DIFF PSEUDOMEMBRANOUS COLITIS
MUPROCIN USE
IMPETIGO
INFECTED SKIN LESIONS
NASAL COLONIZATION MRSA
G+ COCCI

TOPICAL
MUPROCIN MOA
INHIBIT TRNA FORMATION

COMPETE WITH ISOLEUCINE FOR ISOLEUCINE TRNA SYNTHETASE
DOC RICKETTSIA INFECTION
TETRACYCLINE
TETRACYCLINE AE
TEETH DISCOLORATION
ENAMEL HYPOPLASIA
PHOTODERMATITIS
BONE GROWTH PROB
MACROLIDE MOA
ERYTHROMYCIN, CLAIRITHROMYCIN, AZITHROMYCIN

BLOCK PEPTIDYL TRANSFERASE - BLOCK TRANSLOCATION/INHIBIT PROTEIN SYNTHESIS

IRREVERSIBLY BIND 50S RIBOSOME @ 23SRRNA SUBUNIT
ERYTHROMYCIN DRUG INTERACTION
INHIBIT P450

INCREASE [] THEOPHYLLINE (COPD)
WARFARIN
CARBAMAZEPINE (CNS TOX, SEVERE ATAXIA)
LOVASTATIN (MYOPATHY, RHABDOMYOLYSIS)
STREPTOMYCIN USE
PLAGUE, TULAREMIA, RESISTANT TB
CLINDAMYCIN USE
ANAEROBIC INFECTIONS ABOVE DIAPHRAGM - C. PROFRINGENS, B. FRAGILIS

NECROTIZING FASCIITIS WITH PENECILLIN
CLINDAMYCIN AE
C. DIFF PSEUDOMEMBRANOUS COLITIS, FEVER, DIARRHEA, COLITIS
AMINOGLYCOSIDE AE
TOBRAMYCIN, STREPTOMYCIN, GENTAMYCIN

NEPHROTOXICITY (ESP WITH CEPHALOSPORIN)
OTOTOXICITY (ESP WITH LOOP DIURETIC)
CN VIII

DELAYED -> PERM
SULFONAMIDE MOA
INHIBIT FOLATE SYNTHASE
TRIMETHOPRIM MOA
INHIBIT DIHYDROFOLATE REDUCTASE

DECREASE PURINE, PYRIMIDINE, AA SYNTHESIS
SULFONAMIDE/TRIMETOPRIM USE
PNEUMONIA - P JIROVECI, NOCARDIA
SULFONAMIDE AE
CRYSTALLURIA (NEPHROTOXICITY)
HYPERSENSITIVITY (RASH, ANGIOEDEMA)
STEVEN JOHNSON SYNDROME - ERYTHEMA MULTIFORME
HEMOLYTIC ANEMIA (G6PD DEF)
MACROCYTIC ANEMIA (FOLATE DEF)
DISPLACES OTHER DRUGS FROM ALBUMIN (WARFARIN)
FLUOROQUINOLONE MOA
INHIBIT DNA GYRASE (G-)
ATTACHES TO A SITE

INHIBIT TYPE IV TOPOISOMERASE (G+)
FLUOROQUINOLONE RESISTANCE MOA
BACT RESISTANCE TO A SITE - DNA GYRASE

DECREASE # PORIN IN OUTER MEMBRANE, INHIBIT TOPOISOMERASE ACCESS TO CELL
FLUOROQUINOLONE AE
ARTHROPATHY
TENDINOPATHY
CNS EXCITATION - INSOMNIA, SEIZURES
AVOID KIDS
DAPTOMYCIN USE
MRSA, VRE, VRS

SKIN INFECTION
SOFT TISSUE INFECTION
DIABETIC FOOT INFECTIONS
BURNS
ISONIAZID MOA
ACTIVATED BY CATALASE PEROXIDASE

INHIBIT MYCOLIC ACID SYNTHESIS
ISONIAZID RESISTANCE MOA
MUTATION CATALASE PEROXIDASE (KATg GENE)
ISONIAZID AE
HYPERSENSITIVITY
PYRIDOXINE DEF PERIPHERAL NEUROPATHY
OPTIC NEUROPATHY
AGE DEPENDENT HEPATITIS
SEIZURE
G6PD DEF HEMATOLOGIC TOX
WHAT DO YOU GIVE TO PREVENT NEUROTOXICITY WITH ISONIAZID
B6
WHO HAS MORE AE IN ISONIAZID PT
SLOW ACETYLATOR
RIFAMPIN MOA
INHIBIT RNAP

INHIBIT INITIATION STEP OF RNA SYNTHESIS
RIFAMPIN RESISTANCE MOA
DECREASE AFFINITY RNAP

DECREASE PERMEABILITY

MUTATION IN BACTERIAL DNA DEPENDENT RNAP FOR DRUG
RIFAMPIN AE
HYPERSENSITIVITY
HEPATITIS
RED-ORANGE DISCOLORATION TEARS, SALIVA, URINE
PYRAZINAMIDE AE
HYPERURICEMIA
GOUT
RASH
JOINT ACHE
HEPATITIS
HEMATOLOGIC EFFECTS
ETHAMBUTIDE AE
IMPAIRED COLOR VISION
DOSE DEPENDENT OPTIC NEURITIS

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