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Glossary of drugs that are prostaglandins

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Aprostadil
PG E1
Natural
Brand: Caverject, Edex, Muse, Prostin VR
TX:
-Male impotency
-Ductus arterious dependent congenital heart deffects
MOA: relaxation of smooth muscle
Dinoprostone
PG E2
Natural
Brand: Prepidil, Cervidil
TX:
-cervical ripening, induce labor
-2nd trimester abortion
-evacuation of uterus in fetal death
Epoprostenol
PG I2
Natural
Brand: Flolan
TX:
-primary pulmonary HTN
-scleroderma
MOA: vasodilation
Carboprost
PG F2 alpha
Modified PG (15 methyl PGF2 alpha)
Brand: Hemabate
TX:
-post partum bleeding
-2nd trimester abortions
MOA: vasoconstriction
Misoprostol
PG E1
Modified PG, prodrug
Brand: Cytotec
TX:
-prevention of NSAID ulcers
MOA: antisectrtory (decreases acid), protects mucosa.
-prodrug
Treprostinil
PG I2
PG Analog
Brand: Remodulin
TX:
-pulmonary arterial HTN
MOA: vasodilation, inhibits platelet aggregation
Travoprost
PG F2
Modified PG Opthalamic,prodrug
Brand: Travatan
TX:
-open angle glaucoma
-ocular HTN
MOA: increase ocular outflow, decreasing IOP
Bimatoprost
PG F2
Modified PG Opthalamic, not prodrug
Brand: Lumigan
TX:
-open angle glaucoma
-ocular HTN
MOA: increase ocular outflow, decreasing IOP
Lantanoprost
PG F1
Modified PG Opthalamic,prodrug
Brand: Xalatan
TX:
-open angle glaucoma
-ocular HTN
MOA: increase ocular outflow, decreasing IOP
Unoprostone
PG F1
Modified PG Opthalamic,prodrug
Brand: Rescula
TX:
-open angle glaucoma
-ocular HTN
MOA: increase ocular outflow, decreasing IOP

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