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Glossary of cholinomimetics

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Acetylcholine
cholinomimetic
direct-acting
M+N
shortest duration
bethanechol
cholinomimetic
direct-acting
M
resistant to AchE
Tx: stimulate post op bladder + GI
carbachol
cholinomimetic
direct-acting
M+N
resistant to AchE
Tx: glaucoma
pilocarpine
cholinomimetic
direct-acting
M
Tx: glaucoma
cevimeline
cholinomimetic
direct-acting
M
Tx: dry mouth syndrome
nicotine
cholinomimetic
direct-acting
N
endrophonium
cholinomimetic
indirect-acting
M+N
alcohol
Tx: diagnostic test for myasthnia gravis
neostigmine
cholinomimetic
indirect-acting
M+N
carbamate=reversible
Tx: post op bladder + GI stimulation and myasthnia gravis
physostigmine
cholinomimetic
indirect-acting
M+N
carbamate=reversible
Tx: glaucoma
pyridostigmine
cholinomimetic
indirect-acting
M+N
carbamate=reversible
Tx: myasthnia gravis
echothiophate
cholinomimetic
indirect-acting
M+N
organophosphate=irreversible
Tx: glaucoma
parathion
cholinomimetic
indirect-acting
M+N
organophosphate=irreversible
longest lasting=most toxic

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