Westminster phys-77 adrenal
Terms
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Mineralcorticoid effect?
main one? -
effect electrolytes of ECF
mainly Na & K
Aldosterone-90% -
Glucocorticoid effect?
main one? -
effect glucose concentration
Cortisol-90% - Androgens
- same effect as testosterone
- zonz glomerulosa
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outer-15%
Aldosterone
Stimulated by angiotension II/K - zone reticularis
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deepest layer
androgens, DHEA, endostrione
small amounts of androgens and estrogens
stimlated by ACTH - zona fasciulata
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middle-(widest) 70%
cortisol &
small amount androgens/estrogens
stimulated by ACTH - Aldosterone secretion stimulated by? 2
- ECF levels af angiotension II and K.
- Cortisol secretion stimulated by?
- hypothamic/Pituitary CRH/ACTH
- Steroids are made from?....which comes from?
- cholesterol comes from LDL'scho
- cholesterol pathway
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into cell-cleaved at mitochondria by desmolase-progenolone
both ACTH and AGII stimulate the conversion of cholseterol to progenolone - sythetic hormones? potentcy? 3
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methypred-x5x potent as cortisol
dexmetasone-30x
predisone-4x - Aldosterone pathway?
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cholesterol-progenolone-
progesterone-11-deoxycortisone-
corticosterone-aldosterone - Cortisol pathway?
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cholesterol-progenolone-
17 hydrozyprogenolone-
17 hydroxyprogesterone-
11 deoxycortisol-cortisol - has both mineralo/gluco effects? 3
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hydrocortisone
predisolone
9-flurocortisol - all adrenocortico hormones are metabolized mainly in the ?
- liver
- Aldosterone functions?
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increased renal reabsorption of Na and secreation of K
-a sodium retainer - Cortisol functions?
- 2000x greater plasma concentration than aldosterone
- Aldosterone deficiency? 3
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hyperkalemia
Na/CL wasting
diarhhea - Aldosterone excess?
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increased ECF volume
increased BP
little effect of ECF Na
hypokalemia
muscle weakness
loss of H ions (alkalosis)
low sweat/salivation - Aldosterone regulated by? 2
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ECF K concentratons, ACII
increased K and angiotension II increases aldosterone secretion. -
Cortisol excess symtoms?
caused by? -
muscle weakness
moon face
buffalo torso
thin legs
antiinflammatory, lowers permeability
stabilizes lysosomal membrane
causes: stress, trauma, pain,infection, nec-fasc, restraint, catecholamines - Primary Aldosteronism?
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Conn's
tumor of zona glomerulosa - Cortisol functions? 6
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-stimulates gluconeogenesis
-mobilizes muscle AA's
-allows epi.norepi to utilize glucose
-decreases G utilization by the cells
-increases blood glucose
reduces protien stores and protien synthesis -
causes intitial conversion of cholesterol to progenolone?
started by? -
protien kinase A
ACTH - CRF regulated by?
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cortisol levels
negative feedback - precursor of ACTH?
- propiomelanocortin (POMC)
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secretes MSH? (melanocye)
affects? -
pars intermedia
fur/winter/hibernation - hypoadrenalism?
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addision's (cause-autoimmunity)
hyposecretion by the adrenal cortex.
blotchy skin/MM's - hyperadrenalism?
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Cushing's
hypersecretion by the adrenal
cortex
-dz-too much ACTH
-syndrome-effects
dexamethasone won't help id there is an ACTH secreting tumor