Glossary of WAIHA
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- What are 3 main categories of immune hemolytic anemias?
- 1. Alloantibody-induced
- What are the 2 types of alloantibody-induced HA?
- 1. Transfusion reaction
- What are the 3 types of Autoantibody-induced HA?
- 1. Warm AIHA
2. Cold agglutinin disease
3. Paroxysmal Cold Hgburia
- What is the cause of most cases of WAIHA?
- What are some known causes of WAIHA?
- Lymphoma, SLE, carcinoma.
- What class of antibody causes WAIHA?
- What are some common signs and symptoms of WAIHA?
- Weak, dizzy, fever,
- What test is used for diagnosing autoimmune hemolytic anemias?
- What are DAT results for WAIHA?
- Polyspecific: 3-4+
- How do DAT results for WAIHA differ from CAD and PCH?
- Those both show only complement components; WAIHA rarely is complement alone.
- What needs to be determined when a patient has a positive DAT?
How is this done?
- Rule out allo-antibody by doing an adsorption.
- How do you decide what type of adsorption to perform?
- -If not transfused in past 3-4 months, autoadsorption.
-If transfused, alloadsorption.
- What is the principle of an autoadsorption?
- -Patient RBCs + Patient serum to remove autoantibody.
-Test for alloantibody in the serum.
- How do you determine how many adsorptions to do in order to test for an underlying allo- antibody?
- Perform DAT, observe the serum reactivity; E.g., if IAT is 3+, then add 1 = 4 adsorptions.
- How do you get Patient RBCs to be free of autoab in order to remove the Auto-Ab from serum?
- By using ZZAP or enzymes to strip it from the antigens.
- When is an allogeneic adsorption performed?
- When the patient's phenotype is unknown.
- What is the treatment for WAIHA?
- Steroids - immunosuppressants
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