Glossary of Thrombocytopenia
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- What is a thrombocytopenia?
- decreased platelet count
- what is a thrombocythemia?
- an increased platelet count
- what is a thrombocytopathy?
- abnormal platelet function - they're defective.
- What are some symptoms of platelet abnormalities and bleeding tendencies?
-Bleed after surgery, cerebral
- What are the 4 types of thrombocytopenia?
- 1. Decreased plt production
2. Altered plt distribution
3. Ineffective production
4. Increased destruction
- What is the most common reason for a thrombocytopenia?
- Increased platelet destruction, usually due to an autoimmune disorder.
- What causes decreased platelets?
- Decreased megakaryocytes in the bone marrow.
- What are 2 reasons for decr. megakaryos in the bmarrow?
- -Marrow aplasia
-when in doubt say drugs!
- What are 5 spcf reasons you can give for dcr. plt production?
- 1. Viral infections
4. May-Hegglin Anomaly
5. Drug/toxin induced.
- what makes platelet distribution altered?
- Spleen sequestrating the platelets, which occurs in hypersplenism.
- What 2 diseases is spleen sequestration seen?
- -Liver disease
- What are 3 causes of ineffective thrombopoeisis?
- 1. Defective formation
2. Abnormal release to circultn
3. Destruction intramedullary
- What anemia is intramedullary destruction of plts seen in?
- Vit B12/folate deficiency.
- What are the 2 major categories of increased destruction plts?
- What are 4 types of immune thrombocytopenia?
- 1. Autoimmune
4. Neonatal infection.
- For thrombocytopenia, what is: -Primary autoimmune
- Primary = ITP = idiopathic thrombocytopenia purpura.
2ndary = caused by infections, lupus, etc.
- What are 2 types of ITP?
In what patients?
- -Acute - children
-Chronic - adults, mostly female
- What ususally causes ITP?
- -Acute from viral illness
-Chronic from Ab-coated platelets that spleeen destroys
- What is the treatment for each ITP?
- -Acute/kids is self-limiting
-Chronic, use Cortisol
- What are symptoms of each ITP?
- -Acute: purpura, ecchymoess, petechiae, mucosal bleeds
-Chronic: insidious onset
- What are some causes of 2ndary ITP?
- Infections, lupus, refractory anemia, cancer, drugs
- What 4 causes of alloimmmune thrombocytopenias?
- -Neonatal alloimmune thrombocytopenia - mom immunizes fetus.
-make Ab to drug
- What are the 3 main categories of non-immune thrombocytopenia?
- What are the 3 types of Microangiopathic?
- DIC, TTP, HUS
- What is TTP? In Who?
- Thrombotic thrombocytopenia purpura - young women
- What IS DIC?
- Dissemin. Intravasc Coagulopathy
-Simultaneous activation of coagulation and fibrinolysis.
- What types of infections induce thrombocytopenia?
Fungal, protozoan, bacterial.
- what is pseudothrombocytopenia?
- -Artifact caused by EDTA causing platelet clumps from improper collection.
- Enzyme defect and accumulated product in Gaucher's disease:
- Enzyme defect and accumulated product in Neimann-Pick:
- Enzyme defect and accumulated product in sea-blue histiocytosis:
- Enzyme defect and accumulated product in Tay-Sach's
- -Hexosanimidase A
- Enzyme defect/accumlated product in Mucopolysaccharidosis:
- Can't break it down
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