Glossary of Sero study questions
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- Does injection of protective Ab cause active or passive immunity?
- Does injecting attenuated or killed Ag stimulate active or passive immunity?
- Does viral infection stimulate active/passive immunity?
- Does bacterial infection stimulate active or passive immunity?
- Does Ab passage from Mom-fetus stimulate active or passive immunity?
- What is the nim mw for a substance to be an antigen?
- 10,000 daltons
- What is an adjuvant?
- Something that enhances ANTIGENICITY - slows Ag release or allows MORE time for Ag interaction w/ the immune system.
- Humoral Immunity components:
- B cells
- Cellular Immunity components:
- T cells
- Identical action exhibited by Humoral and Cellular Immunity:
- Proliferation and Memory
- Which cell has Erythrocyte receptor? What is the receptor's name?
- T cells - CD2 - E-rosettor
- In lymph nodes, where do:
-T cells reside?
-B cells reside?
- T: paracortex
B: germinal center
- T cells mature where?
- B cells mature where?
- Bone marrow
- What is necessary for Antigen presentation to T cells by macrophages/monocytes?
- MHC II
- All immunoglobulins have what basic structure?
- 2 Heavy chains
2 Light chains
-Bound by disulfide bonds.
- Which Ig binds MAST cells, via what?
- IgE - via Fc portion.
- IgG subclasses vary based on:
- Number of disulfide bonds.
- Which Ig's have J chains?
- IgM and IgA
- How many units are in:
- IgG = 1 unit
IgM = 5 units
IgA = 2 or 3 units
- Which Ig's AGGLUTINATE?
- IgG - Incompletely
IgM - Completely
- What is ALLOTYPE?
- Ig Constant region differences between persons of the same species.
- What is Isotype?
- Heavy chains differences among people.
- What is Idiotype?
- Differences in the VARIABLE regions of antibodies between people.
- Ig present in human serum in highest concentration?
- Which Igs fix complement?
- IgM and IgG
- Which Igs cross placenta?
- Give 3 characteristics of PRIMARY immune response:
- 1. Occurs w/ 1st Ag contact
2. IgM, transient, evidence of ACUTE infection.
3. Slow comp w/ hypersens. or secondary immune response.
- Give 2 characteristics of SECONDARY immune response:
- 1. Requires previous Ag contact.
2. IgG, Fast, Long lasting
- What is Affinity?
- Strength of single epitope binding/fit
- What is avidity?
- Strength of a multivalent Ag-Ab bond
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