Glossary of SFS - Parkinson's Disease II
Other Decks By This User
- Does PD get worse with aging?
- Causes of PD?
Environmental toxins - rural farming, well water, chemicals
- What % of PD worldwide is genetic?
- Essay....Why would L-dopa cause vomiting?
- L-dopa is converted to DA in the periphery, which stimulates the area postrema (vomiting center).
- Gold standard for PD treatment?
- PD is the likely result of what 2 factors?
- genetic predisposition and environmental exposure
- In Park 1, a single nucleotide change occurs in what protein found in Lewy bodies of PD patients?
- alpha-synuclein (may be involved in trafficking of DA vesicles)
- Explain the rural hypothesis of PD onset.
- Pesticides and herbicides in large concentrations in well water, could set off an already existing genetic predisposition for PD.
- PD can result from destruction/damage to what resulting in substantia nigra and locus ceruleus cell death?
- By bacteria going after the proteosome or MPTP going after the mitochondria of these cells.
- Describe oxidative stress theory.
- Chemicals can cause cascade of bad things...causative factors are MPTP and dopamine.
- General mechanism of MPTP.
- Found in a synthetic demerol. MPTP crosses the BBB, and completely destroys the substantia nigra resulting in PD symptoms.
- Chemicals useful in creating animal models for PD.
- Reserpine and MPTP
- MPTP is taken up by what type of cell?
- astrocytes. Astrocytes convert MPTP to MPP+(toxic) with MAO-B (inhibitors of MAO-B may help PD).
- What is the toxic compound of MPTP action?
- MPP+. DA transporter mistakes it as DA and takes it into the cell, poisoning the mitochondria.
- What enzyme is missing in PD patients that typically neutralizes hydrogen peroxide from DA breakdown?
- Cause DNA damage, Ca++ entry into cell, and lipid memb. breakdown.
- hydroxyl free radicals. Activate degradative enzymes dissolving cell from inside out.
- ________ are formed by an accumulation of mutated alpha-synuclein.
- Lewy bodies. In PD, the cell can't get rid of synuclein.
- Result of a non-functional or absent proteosome.
- Build-up of undesired proteins in the cell. Lewy body as well.
- A chemical used by the mitochondrion in the ETC that can slow PD progression by 30%.
- Coenzyme Q10
- Can "bring cells back to life" but can't cross BBB.
- Glial-derived neurotrophic factor.
- Ideas in PD gene therapy.
- Blocking GABA, increasing tyrosine hydroxylase (or DA), and GDNF.
- Deep brain stimulation here will improve symptoms for what condition(s)?
- a. tremor
c. Parkinson's symptoms
- Why aren't pallidotomies and thalamotomies ideal?
- The lesions will heal, causing symptoms to return. Also, if done bilaterally will cause side effect profile to go up.
- Did adrenal gland transplants for PD work?
Did DA-producing fibroblasts?
- Um...NO and NO.
- Side effect of using fetal stem cells for PD.
- Produced "off" dyskinesia in absence of L-dopa treatment. (From scripts) this seems like it is "on" and "off" symptoms...rigidity and immobility paired with chorea.
- Excessive amounts of L-dopa can cause what?
- ON dyskinesia.
- Therapy using DA-producing retinal epithelial cells grown on plastic beads injected into the brain.
- Number of contacts in the STN for deep brain stimulation.
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