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Renal Path Lab 2

Renal Path Lab 2

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?: Acute Pyelonephritis

Note bulging of cortex in area of microabscess. Dark blue area consists of neutrophils.
?: Acute Pyelonephritis

In center, tubules are filled with acute inflammatory cells with surrounding congestion.
?: Acute Pyelonephritis

In center, tubules are filled with acute inflammatory cells with surrounding congestion.
?: Chronic Pyelonephritis

Diffuse fibrosis, few glomeruli with periglomerular fibrosis, and numerous lymphoid follicles.
?: Chronic Pyelonephritis

Atrophy of tubules. Note relative sparing of glomeruli. Dense interstitial lymphocytic infiltrate. PAS stain.
?: Chronic Pyelonephritis

Atrophy of tubules. Note relative sparing of glomeruli. Dense interstitial lymphocytic infiltrate. PAS stain. Note the foci of marked tubular atrophy.
?: Papillary Necrosis of Kidney

This is a whole mount of the actual histological section, showing the morphological demarcation of the necrotic and infected medullary area from the rest of the kidney.
?: Papillary Necrosis of Kidney

Well demarcated zone of necrosis and inflammation.
?: Papillary Necrosis of Kidney

Higher power view in the kidney showing necrotic and infammatory debris.
?: Renal Cell Carcinoma

Low power shows "pushing" border of carcinoma adjacent to non-neoplastic kidney.
?: Renal Cell Carcinoma

Mid-power shows cords and "alveolar" pattern of grouping of malignant clear cells. Thin capillaries within the tumor produce a delicate vascularity.
?: Renal Cell Carcinoma

Cells contain abundant, clear cytoplasm; obvious nuclear pleomorphism is not seen in this field.
?: Wilm's Tumor of Kidney (Nephroblastoma)

Low power shows a classic example with its triphasic components of blastema (tightly packed solid sheets of small cells), immature tubules, and loose stroma.
?: Wilm's Tumor of Kidney (Nephroblastoma)

High power shows the malignant cells containing hyperchromatic nuclei without nucleoli and inconspicuous cytoplasm. Stromal component contains spindle cells.
?: Wilm's Tumor of Kidney (Nephroblastoma)

This example shows stromal cells differentiating toward skeletal muscle, and abundant immature tubule formation.
?: Urothelial (Transitional) Cell Carcinoma of Urinary Bladder

Low power view shows the typical appearance of papillary transitional cell carcinoma of the bladder.
?: Urothelial (Transitional) Cell Carcinoma of Urinary Bladder

Invasion of the bladder wall. Note the spindle shaped smooth muscle cells at one edge of the field and adjacent carcinoma with surrounding inflammation.
?: Urothelial (Transitional) Cell Carcinoma of Urinary Bladder

Another view of the tumor with accompanying cellular reaction.
?: Urothelial (Transitional) Cell Carcinoma of Urinary Bladder

Carcinoma in-situ of urinary bladder. Note loss of polarity, nucleomegaly, hyerchromasia, and mitosis.
?: Normal Prostate Slides

Posterior segment of prostate with prostatic pseudocapsule at one edge of the photo. Note arrangement of prostatic glands.
?: Normal Prostate

Normal prostatic glands. Note the regular columnar epithelium, nuclear size, and interstitial stroma, and lack of nucleoli.
?: Benign Prostatic Hypertrophy

Low power of prostate shows nodular hyperplasia of the tubuloalveolar glands with variable dilatation of gland lumens.
?: Benign Prostatic Hypertrophy

Nodular expansion of fibromuscular stroma seen at low power.
?: Benign Prostatic Hypertrophy

Glands separated by stroma and lined by an inner simple columnar and outer flattened basal epithelium. Papillary infolding of the epithelium is common.
?: Adenocarcinoma of Prostate

The tumor consists of small glands infiltrating into the stroma in a disorganized fashion. The normal lobular architecture has been destroyed.
?: Adenocarcinoma of Prostate

Perineural invasion by carcinoma.
?: Adenocarcinoma of Prostate

Obvious nucleoli in these malignant glands.
?: Normal Testis

Normal testis, low power.
?: Normal Testis

Active spermatogenesis.
?: Seminoma

Gross of tumor.
?: Seminoma

Low power view showing the uniform cells of which the tumor is composed admixed with small, mature lymphocytes.
?: Seminoma

Higher power view. Uniform cells with large central nuclei and a lymphocytic infiltrate.
?: Embryonal Carcinoma of Testis

Gross of carcinoma.
?: Embryonal Carcinoma of Testis

These are irregular tubules and cell clusters. The individual cells are large, hyperchromatic, have abundant cytoplasm and very irregular, dense nuclei. There is a great variety of cell types present and mitoses are very frequent.
?: Squamous Cell Carcinoma of Penis

Partial penectomy shows polypoid lesion on the surface of the glans penis.
?: Squamous Cell Carcinoma of Penis

Keratinizing squamous cell carcinoma infiltrates the stroma.
?: Degenerative Changes Slides

Acute pyelonephritis. Note intense hyperemia and multifocal abscesses.
?: Degenerative Changes

Cut surface of a large, single abscess.
?: Degenerative Changes

Chronic pyelonephritis. Note irregularly scarred contracted kidney.
?: Degenerative Changes

Hydronephrosis. Note distended pelvis. The thin translucent pelvis suggests that this hydronephrosis is of acute, recent origin.
?: Degenerative Changes

Hydronephrosis (Staghorn calculus). In contrast to previous illustration, the pelvic mucosa is more opaque and thickened, suggesting chronic obstruction and possible infection. The dilatation involved only one kidney indicating the obstruction is unilateral (e.g., calculus, ureteral stricture, or unilateral obstruction of ureteric orifice).
?: Degenerative Changes

Renal cell carcinoma. The characteristic yellow color of renal cell carcinoma is seen. Note the variegated appearance with foci of hemorrhage and necrosis.
?: Degenerative Changes

Acute hemorrhagic cystitis. Note the intense mucosal hyperemia.
?: Degenerative Changes

Urothelial (transitional cell) carcinoma of bladder. Note the mucosal irregularity and the nodular/papillary appearance of the tumor.
?: Degenerative Changes

Transitional cell carcinoma of ureter. Polypoid intraluminal mass in mid-ureter. Lack of hydronephrosis indicates that the tumor did not produce complete outflow obstruction of urine over any prolonged period of time.
?: Degenerative Changes

Transitional cell carcinoma of ureter. Polypoid intraluminal mass in mid-ureter. Lack of hydronephrosis indicates that the tumor did not produce complete outflow obstruction of urine over any prolonged period of time.
?: Degenerative Changes

Prostatic hypertrophy. Note the prominent protrusion of the prostatic median lobe (arrow) into the baldder cavity and the diffuse hypertrophy of the bladder wall. The ureters show moderate bilateral dilation.
?: Degenerative Changes

Carcinoma of prostate. Note the extensive mass of white tumor tissue.
?: Degenerative Changes

Small adenocarcinoma of the prostate (arrow). Note the typical peripheral location.

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