Glossary of Polio
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- Describe the structure of Polio virus.
- What is the Viropexis?
- Endocytic property that facillitates the energy dependent process of penetration and uncoating.
99% of polio infx are subclinical.
- True and only a minority of cases develop into aseptic meningitis, even fewer into paralytic polio.
- What is Progressive Post-Poliomyelitis muscle atropy? What is this do to?
- -25-40% of earlier infxs suffer additional muscular degeneration - yrs later.
-Not due to persistence of virus, rather effect of aging.
- Where is the site of the primary replication of polio? Primary viremia?
- -Oropharynx mucosa, tonsils and lymph nodes of neck.
-Viremia in Peyers Patches and mesenteric lymph nodes.
- Two ways paralysis can occur?
- -direct destruction of neurons by virus or
-edema induced damage.
- 3 ways we see polio infx in US.
- -Immunocompromised vacinnee
-grandparent with dec. imm., changes recently vaccinized baby.
- 3 advantages of IPV
- -IPV can be incorporated with multiple vaccines.
-excludes potential for mutations.
-Can be used in immcompromised patients.
-Reduces spread of live polio.
- 3 disadvantage of IPV
- -Repeat boosters are required.
-No local intestinal immunity.
- 3 advantages to OPV.
- -Confers both humoral and intestinal imm.
-Imm may be life long.
-Quickly induces Abs.
- 3 disadvantages of OPV.
- -Virus might mutate.
-Vaccine can spread virus to others and environment.
-Can't give to immunosuppressed.
- Starting from the 70s, tell the story of the polio vaccine.
- OPV was implemented in the 70s and after several cases of polio each year, IPV was re-implemented in 2000.
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