Pharmacology - physiology of ANS
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- Name the organs innervated by the alpha-1 receptors.
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1. Radial muscle, iris
2. Canal of SChlemm
3. Arterioles
4. Bronchial glands
5. Proximal tubules
6. Trigone
7. Urethra
8. Vas deferens
9. Pilomotor muscle
10. Salivary glands - Name the organs innervated by alpha 2 receptors.
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1. Canal of Schlemm
2. Arterioles
3. Stomach and intestine - motility and tone, secretion
4. Platelets
5. Islet cells (insulin) - Name the organs innervated by alpha receptors.
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1. Smooth muscle of the eyelid
2. Pregnant uterus
3. Pancreatic acinar cells - Name the organs innervated by Beta 1 receptors.
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1. Heart
2. JG cells
3. Adipocytes - Name the organs innervated by Beta 2 receptors.
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1. Arterioles
2. Bronchial muscle
3. Pregnant and nonpregnant uterus
4. Gallbladder and ducts.
5. Skeletal muscle
6. Liver - Name the organs innervated by beta receptors?
- Islet cells (glucagon)
- Name the innervation for sweat glands.
- Muscarinic (adrenergic)
- Name organs that are innervated by parasympathetics only.
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Sphincter muscle, iris
Ciliary m
Esophagus
Acid secretion in stomach
Detrusor muscle
Penis
Urethral and bulbourethral gland
Clitoris and area around introitus
Bartholin's gland
Lacrimal gland
Nasopharyngeal gland. - What happens with older anti-histamine?
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They activate histamine receptors and also muscarinic cholinergic receptors.
Therefore the side effects of sleepiness, dry nose, dry mouth. - Describe the parasympathetic innervation in the penis.
- NO causes the relaxation of the arterioles therefore allowing the pooling of blood the penis.
- What does the NE released from the sympathetic fibers do?
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1. Bind alpha 2 receptors on vagal cardiac fiber (inhibitory)
2. Bind Beta 1 receptors on the SA node (excitatory)
3. Bind alpha 2 receptors on itself (autoreceptor) to decrease the release of more NE. - What does the Ach released from the parasympathetic fibers do?
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1. bind to M2 receptors on sym fibers (inhibitory)
2. bind to M2 receptors on the SA node (inhibitory)
3. bind to M2 receptors on itself (autoregulation) - What is the MOA of alpha 2 receptors on effector organs?
- Increase inhibition of AC therefore decrease cAMP
- What is the MOA of alpha 2 receptors on autoreceptors?
- Increase K conductance
- What is the MOA of alpha 2 receptors on SA node, sphincter muscle of iris and GI tract?
- Increase K conductance.