Pharm: Eicosanoids
Terms
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- marijuana
- arachidonate + ehanolamine = anandamide (marijuana)
- zileuton
- lipoxygenase inhibitor (asthma)
- zafirlukast
- leukotriene receptor inhibitor (asthma)
- montelukast
- leukotrience receptor inhibitor (asthma)
- dinoprostone
- PGE2 analog (abortifacient or induce labor)
- latanoprost
- PGF2a analog (open angle glaucoma)
- misoprostol
- PGE1 analog (abortafacient, protection from ulcers)
- alprostadil
- PGE1 analog (erections, maintain patency of patent ductus arteriosis) vasodilation
- epoprostenol
- PGI2 analog via IV (primary pulmonary hypertension)
- treprostinil
- PGI2 analog via SUB Q(primary pulmonary hypertension)
- bosentan
- endothelin antagonist, used with epoprostenol or treprostenol (primary pulmonary hypertension)
- mifepristone (RU486)
- abortifactant (used with misoprostol)
- methotrexate
- abortifactant (used with misoprostol)
- PGI2
-
potent vasodilation (cAMP)
platelet aggregation
bronchodilate
relax uterus
increase renal blood flow - PGE1
-
vasodilation (cAMP)
platelet aggregation
bronchodilate
GI muscle contraction
relax uterus
temperature increase
inhibit NE release - PGE2
-
vasodilation (cAMP)
bronchodilate
GI muscle contraction
uterus contraction
increase renal blood flow
temperature increase
inhibit NE release - PGE2a
- vasoconstriction (CA, IP/DAG)
- PGF2a
-
vasoconstriction (CA, IP/DAG)
bronchoconstrict
uterus contraction
reduce intraocular pressure - TXA2
-
vasoconstriction (CA, IP/DAG)
potent platelet aggregant (aspirin inhibited)
bronchoconstrict
uterus contraction
decreases renal blood flow - LTC4, LTD4
-
vasodilate at low concentration, vasoconstrict at high concentration
potent bronchoconstriction
broncho-secretion