Pathology: neoplasia
Terms
undefined, object
copy deck
-
S100 antigen pos
neural crest/ ectoderm
sm CC of lung
carcinoid tumors
melanoma
neuroblastoma - APUD tumors- neuroendocrine
- MC sarcoma in kids
- embryonal rhabdomyosarcoma
- MC sarcoma in adults
-
malignant fibrous histiocytoma
then liposarcoma - pleomorphic adenoma of salivary gland (parotid)
- mixed tumor
- MC malignant lymphoma
- non-hodgkins- B cell follicular lymphoma
- synctiotrophoblasts secrete
- bHCG
-
bronchial hamartoma
peutz-jeghers polyp
hyperplastic polyp - haratomas
-
30 doubling times
10^9 cells
1g tissue
1 ml volume - clinically evident tumor
- lymph node
-
usually a met from breast/lung cancer
primary= non hodgkins - lung
-
usually a met from breast cancer
primary = adenocarcinoma - brain
-
usually a met from lung cancer
primary = gliobastoma multiforme in adults;
medulloblastoma in kids - liver
-
usually a met from lung
primary = hepatocellular carcinoma secondary to HBV - bone
-
usually a met from breast cancer
primary = multiple myeloma; osteogenic sarcoma - adrenal glands
-
usually a met from lung cancer
primary = adenocarcinoma - most common cancer in lung and bones
- breast cancer
- MC cancer in liver and brain
- lung cancer
- CD45
- leukocyte malignancies
- s100
- neuroendocrine tumor
- s100 + CD45
- malignant melanoma
- erb2-neu (HER2)
- invasive ductal cancer- poor prognosis
- t(9;22)
-
philadelphia chromosome
bcr-abl fusion gene
*CML - ret point mutation
- MEN syndromes
- ras point mutations
-
30% of all human cancers
lung
colon
pancreas
AML - t(8;14)
-
bcl2 overexpression
Burkitt's lymphoma
EBV - N-myc
- neuroblastoma
- Rb mutation
-
retinoblastoma
osteogenic sarcoma
breast cancer - p53 mutation
-
15-50% of all human cancers
colon
brest
lung
CNS
*Li-Fraumeni syndrome - APC gene chr 5
-
adenomatous polyposis coli
*familial polyposis
*Gardner's syndrome -
NF1 on chr 17
NF2 on chr 22 - neurofibromatosis
- BRCA-1
-
breast
ovarian
colon
prostate - transitional carcinoma of bladder
-
cigarette smoke
cyclophosphamide - angiosarcoma of lvier
- vinyl chloride
- lung cancer
- cigarette smoke
- hepatocellular carcinoma
- aflatoxins; esp with HBV
- leukemia
- benzene
- SqCC of oral pharynx
- cigarette smoke
- SqCC of esophagus
-
cigarette smoke
alcohol - MC paraneoplastic syndrome
- hypercalcemia (usually from mets to bone, or from PTHrP)
- eaton lambert
- MG paraneoplastic syndrome assoc with SmCC of lung
-
Leser-Trelat sign
canthosis nigricans - gastric adenocarcinoma
- Trausseau's
- pancreatic adenocarcinoma
- MEN I
-
pituitary
parathyroid
pancreatic - MEN II
-
medullary thryoid
parathyroid
pheochromocytoma - MEN III
-
medullary thrygoid
mucosal neuromas
pheochromocytoma - von Hippel Lindau
-
cerebellar hemangioblastoma
bilateral renal adenocarcinoma
pheochromocytoma