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Glossary of Neuro Pharm 9

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Phenytoin
- AED for partial and tonic-clonic seizures
- interacts w/ CYP2C9 and CYP2C19
Carbamazepine
- AED for partial and tonic-clonic seizures
- interacts w/ CYP3A4, CYP2C8, CYP1A2
Lamotrigine
- AED for partial and mixed seizures
- May interfere with pathologic glutamate release
- interacts w/ UGT 1A4
topiramate
- AED for partial and tonic-clonic seizures
- antagonizes glutamate action at AMPA/kainate GluR’s and inhibits carbonic anhydrase
Barbiturates for epilepsy
- phenobarbitol
- for partial and tonic-clonic seizures, and status epilepticus
- prolong GABA-mediated chloride channel openings
gabapentin
- for partial and tonic-clonic seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc
valproate
- for partial, tonic-clonic, and abscence seizures
- increase neuronal GABA concentration - enhances GABA transmission, etc
ethosuximide
- for abscence seizures
– Blocks “transient” (T-type) calcium channels
benzodiazapine for epilepsy
- diazepam
- for status epilepticus
fosphenytoin
a phenytoin for status epilepticus

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