Glossary of Neuro Gold
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- What are the forces acting on ions in solution?
- Chemical: diffusion
Electrical: ions have repulsive and attractive forces
- 3 factors that determine the basis of membrane potential
- combo of physical (chemical & electrical) and biological (semi-permeable membrane)
- the measure of ease with which charge will flow in a system.
Reciprocal of Ohns
Ohm's Law would be: V = I/g
- Negative current vs. Positive current
- Negative current = positive charges moving in
Positive current = positive charges moving out
- Inward current vs. outward current
- Inward current: positive ions moving into the cell
Outward current: positive ions moving out of the cell
- Driving force
- Vm - Veq
- Equation for current flow
- I = g * (Vm-Veq)
where g is conductance
- Intracellular and Extracellular Concentration of K+
- intra: 140
- Intracellular and Extracellular Concentration of Na+
- intra: 5-15
- Intracellular and Extracellular Concentration of Cl-
- intra: 4-30
- Intracellular and Extracellular Concentration of Calcium
- intra: 0.0001
very highly regulated
- Definition of threshold
- the potential at which inward Na+ current matches outward K+ current.
- 3 factors that influence PEP (passive electrical properties, aka cable properties)
- internal resistance
- absolute refractory period
- period of time during which it is not possible for a neuron to fire another action potential.
- relative refractory period
- a period following the absolute refractory period during which it is possible for a neuron to fire another action potential, but only if suprathreshold stimuli apply.
- what is membrane capacitance?
- the ability of the membrane to store charge.
- myelination in CNS vs. PNS
- CNS = oligodendrocytes
PNS = schwann cells
- 2 ays in which myelination speeds conduction velocity
- 1) increase MEMBRANE resistance
2) decrease capacitance-- it increases the charge separation
- CA2+ ATPase
- Removes Ca2+ from the cytosol pumping it into intracellular stores.
- Electrogenic Pump
- a pump that contributes to the resting membrane potential
- "Silent," "Mechanically Insensitive" nociceptors
- Sensitized by inflammatory mediators
- Type I AMHs
- Type I Adelta mechano-heat nociceptors
delay before firing, but once started, continue to fire
- Type II AMHs
- Type II Adelta mechanoheat nociceptors
fire immediately and stop firing pretty quickly
- Efferent role of nociceptors
- 1) axons reflex
2) axonal coupling
3) antidromic action potentials
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