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Glossary of Neuro: dementia

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Dementia is a chr, progres, global decline in which cognitive ares? (5 A's)
Aphasia
Amnesia
Agnosia
Apraxia
Abstract thought disturb (executive func prob)
what is most common cz of dementia
alzheimer
what is ddx of dementia?
(DEMENTIA)
neuroDEGENRATIVE dz
Endocrine
Metabolic
Exogenous
Neoplasm
Trauma
Infection
Affective d/o
Stroke/Structural
What is the most impt rf for alzheimer
age
other rf for dementia
FAMILY HX
DOWN SYNDROME (>35)
female
low education level
Path seen in alzheimer
NEUROFIBRILLARY TANGLES
NEURITIC PLAQUES W/ AMYLOID DEPOSITS
amyloid angiopathy
neuronal loss
what is usu the 1st sign of Alz?
amnesia
DDx of Alz
(some cz of dementia)
multi-infarct dementia
Pick's
pseudodementia (depression)
NPH
subdural hemorrhage
intracranial abscess
tumor
T or F
Alz is a dx of exclusion
T
Why is Alz a dx of exclusion? (how is is definitely dx)
dx only at autopsy
t or f
neuropsych testing can disting b/w dementia and depression
T
what labs would you perform in dx alz/dementia?
cbc, esr, lytes, tsh, serum b12
tx of alzheimer's--first line
cholinesterase inhibitors
(donepezil, rivastigmine, galantamine)
what vit _may_ slow decline
vit E
T or F
selegiline, other anti-ox, anti-inflam, estrog have not shown equivocally to afffect dz course
T
#yrs survival frm onset of sx
5-10
death d/t? (secondary)
aspiration pneumonia

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