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Glossary of Microbiology Immune Response

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acquired immunity
immunity that develops from exposure to an antigen
key properties of
acquired immunity
specificity and memory
antigenic determinant /
epitope
specific molecular groups to which an antibody reacts
antigen / immunogen
any substance that reacts with products of an immune response /

immunogen stimulates the response
antigen-presenting cell
APC
A cell that presents peptide fragments associated with MHC class II proteins
protein receptor
membrane bound proteins on the surface of cells that recognize specific antigenic determinants
MHC
major histocompatability complex
cell surface proteins for self-recognition and immune responses
humoral response
protective response mediated by antibody molecules that circulate with the body fluids
cell-mediated response
protective response mediated by specialized cells
immunity
all of the mechanisms used by the body as protection against microorganisms and othe foreign agents
nonspecific external
defense mechanisms
First line of defense
includes physical barriers, chemical agents and bacterial interference
nonspecific internal
defense mechanisms (5)
Second line of defense
phagocytosis
lymphatic system
inflammation
white blood cells and
other blood components
Protective physical barriers (7)
Skin
Mucous membranes
eyes (lysozyme)
outer ear canal
alimentary canal
genitourinary tract
respiratory tract
White blood cells
Granulocytes (neutrophils / basophils)
Monocytes (macrophages)
Lymphocytes (B cells / T cells)
Neutrophils
WBC 1% of body weight
1st of acute inflammatory response
phagocytize bacteria
Macrophages
wandering and fixed
- phagocytic
- present antigen to lymphocytes
B cells
lymphocytes found in lymph nodes and spleen
preprogrammed to respond to a specific antigen
T cells
lymphocytes found in thymus
respond to specific antigens that have been presented to them

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