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Glossary of Micro 6

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MRSA → Staph A. resistant to methicillin (and most related antibiotics)
- Carry a new gene (____) encoding an altered PBP
mecA
_____ found that filtration of tobacco plant extract
did not remove the agent causing tobacco mosaic disease( ⇒ “filterable virus”)
Iwanowski
Viruses have ____(will only infect one type of cell or host)
host specificity
- single stranded RNA (“Plus” orientation = ____)
- single stranded RNA (“Minus” orientation = ____)
mRNA

anti-mRNA
A virus will contain only ___ type of nucleic acid
one
Protein coat that surrounds nucleic acid core consists of individual protein subunits (____) which
combine to make a complete shell (______)→ Three basic shapes:Helical,Icosahedral, Complex
Capsomers

Capsid
One exception to the size rule: _____ (“mimicking microbe”)- recently discovered as a virus of amoebas - larger in size than the smallest bacteria
Mimivirus
Outside of host cell, viruses exist as “____”
Virions
Lytic Infection= “____” phage
Virulent
Use ____ to Determine Number of Lytic Phage in a Population
Plaque Count Assay (total # of plaques = total # of virions in original) sample
Lysogenic Infection= “____” phage
Temperate phage (eg. phage Lambda)
In lysogenic inf. Virus genome recombines into bacterial chromosome
( = “____”)
Prophage
___ is when phage carry genes that alter phenotype of bacterial host
Lysogenic Conversion
Spike + receptor interaction determines virus____ and tissue specificity (only cells with a complementary
receptor can be infected)
host range
For Penetration of enveloped virus, method can be ___ or ___
fusion or endocytosed
______ is the separation of viral genome from its protein coat
“Uncoating”
DNA virus genome contains:
- “____” genes → transcribed immediately after entry into cell
- “____” genes → transcribed only after new viral RNA pol. made
Early

Late
If viral genome is RNA: Different strategies depending on whether “_____” or “____” RNA
“Plus” or “Minus” RNA
Budding of enveloped virus may or may not kill host cell - If host cell survives → possible continual virus production & release over time (= “_____”)
virus shedding
Host Cell Transformation(oncogenes):
• Formation of cancerous host cells by “tumor” viruses
HTLV-1 (RNA) ⇒ _____
Papilloma virus (DNA) ⇒ ____
Epstein-Barr Virus (DNA) ⇒__
T-cell leukemia
cervical cancers
Burkitt’s lymphoma

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