Glossary of Micro: Systemic Mycoses
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- Histoplasmosis mimics which disease?
- resembles miliary tuberculosis
- What are two important characteristics of the pathology of histoplasmosis?
- primary lung process manifest as respiratory ilness and miliary spread
may be primarily in the hilar lymph nodes and may be chronic with cavitation or heal with calcification
- H. capsulatum is ecologically associated with what types of environments?
- Mississippi / ohio river valey
Southeast US river basins
- Who gets life threatening infections due to H. capsulatum?
- AIDS patients
- What are the characteristics of the mold and yeast phase of H. capsulatum?
- mold grows on media agar slants at 20-30 degrees; grows as saprophytic mold in soils
Yeast phase present in man, grows on Brain Heart infusion agar or enriched agar at 37 degrees
- How are Histoplasmosis classified?
- BENIGN INFECTIONS
-usually mild and asymptomatic but rarely causes Symptomatic Primary
- Disseminated Histoplasmosis (immune defect- AIDS)
- Chronic Pulmonary Hisotplasmosis (structural Defect)
EXCESSIVE FIBROSIS: Healed Primary
- Mediastinal Fibrosis or Collagenous
- What is a characteristic X ray finding in Histoplasmosis?
- diffuse calcification
- B. dermatididis is characterized by what type of tissue form?
- necrotic ulcers due to dissemination (Erythma nodosum)
- What is characteristic of pulmonary disease caused by P. brasiliensis?
- begins abruptly with high fever, cough and respiratory insufficiency
more usual is the anorexia, weigth loss and malaise
- Whay is the epidemiology of paracoccidioidomycosis?
- South America and Mexico
found in warm, wet tropical areas; tropical or subtropical rainforests
most important systemic mycoses in Latin America
- What is the clinical presentation of paracoccidioidomycosis?
- chronic granulomatous disease and pulmonary disease
extensive fibrosis of the lungs
- What are the characteristics of the tissue phase and yeast phase of P. brasiliensis?
- tissue phase is budding yeast
- What are the ecology and epidemiology of Coccidioides immitis?
- resides in warm, alkaline arid soils as a saprophyte in the Southwestern United States, Mexico, and Central America
grows 3-4 inches under soil, comes to the surface follwing late spring rains and carried by wind to unsuspecting host (usually a visitor to the region)
dark skinned individuals are more susceptible
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