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Glossary of Mechanisms of Disease Exam 1 2

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Hyperuricemia
uric acid >6-7mg/dl
Colchicine
traditional treatment used since middle ages. Reduces neutrophil emmigration, blocls chemical junk
Purines
breakdown causes production of uric acid
solubility of uric acid
6.5 mg/dl at 37 C
majority of gout patients
men near the age of 40
factors increasing hyperuricemia risk
alcohol, obesity, renal dysfunction
cause of hyperuricemia
underexcretion (90%)
Overproduction
acute attack of gout
usually attack 1 joint
urate crystals in soft tissue
gouty tophi
monosodium urate crystals
negatively birefringent
Benecid (probencid)
uricosuric drug to increase uric acid secretion
Zylloprim (allopurinol)
inhibits xanthine oxidase
calcium pyrophosphate crystals
found in pseudogout
positively birefringent
calcium pyrophosphate crystals
APAP
tylenol

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