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Glossary of Mechanisms of Disease 2

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Most Common form of arthritis
OA
As __ progresses, crystals of calcium phosphate are shed into the joint fluid and are commonly found in
severe __
OA
PATHOLOGY OA

Gross Level
- first see cartilage irregularities and splitting.
- next see ulceration of cartilage and frank cartilage loss
- next, bone-on-bone contact then eburnation (polished bone)
PATHOLOGY OA

Microscopic Level
- see fibrillation of cartilage
Inflamation in OA
Inflammation is not a significant component of OA. it is not considered an inflammatory condition or disease.
OA PATHOLOGY

biochemically
-decreased glycosaminoglycan content of cartilage including
less keratan
less hyaluronic acid
less chondroitin sulfate
Though __ parallels age, it is not considered a NL feature of aging
OA
Develops routinely in people whose occupations cause repetitive stress/trauma/impact to one or more joints
OA
Obesity increases risk for __, especially in the knees
OA
Most common joints affected in OA
lumbosacral spine
hips
knees
feet
but also cervical spine and PIP and DIP joints
MMP
Matrix Metalloproteinase

increased in OA

play significant
role in degradation of extracellular matrix of cartilage
OA is primarily a disease of the _____ _____ of joints.
hyaline cartilage
Pathogenic Theory of OA
mechanical stress which > change in chondrocyte metabolism >
proteolytic enzyme production (MMPs) >
disruption of cartilage matrix
As OA progresses, crystals of _______ _______ are shed into the joint fluid and are commonly found in
severe OA
calcium phosphate
Morning stiffness < 30 min is a common symptom of _____
OA
Gelling
stiffness after short periods of rest
Possible reasons for OA associated pain
periostitis
subchondral microfractures
osteophytes (synovial nerve ending irritation)
muscle spasm
synovial inflammation (by chem junk)

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