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Glossary of Lab Practicum Hematology slides

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what are the arrows pointing to?
platelet

what are the arrows pointing to?
giant platelets
Post spleenectomy is most common reason to find them
Also mb dt: May-Hegglin, leukemic myelofibrosis.

what is the arrow pointing to?
segmented neutrophil
usually only one seen in an RBC. DNA nuclear fragments.
Found in megaloblastic anemia, sickle-cell anemia, and post splenectomy.
Erythrocyte Howell-Jolly bodies:

what is the arrow pointing to?
segmented neutrophils

what is the arrowing pointing to?
Band
The indentation is greater than 1/2 of the width of the hypothetical round nucleus. Opposite edges of nucleus become parallel giving horseshoe appearance.

what is this? (arrow)
Band
Neutrophilic bands constitute what percentage of WBCs in a normal peripheral blood smear?
1-5%

which is the segmented neutrophil and which is the neutrophilic band?
the seg is on the left, the band on the right

what are the pale blue inclusions in these cells' cytoplasm?
Dohle bodies, RER residual aggregates, but may increase in infectious dz, burns, cytotoxic chemicals, poisons.

what type of WBCs are these? what causes them to look like this?
Hypersegmented neutrophils (5 or more lobes)
Due to decreased B12 and Folate.

I.D. these cells
Peutz-Huet anomaly.
Hereditary anomaly characterized by hypolobulation of the nucleus of granulocytes. Pince-nez (bottom left).

what is this WBC?
neutrophilic metamyelocyte.
slightly indented nucleus, small pinkish-blue granules. Rarely seen in normal peripheral blood.

what are these (arrows)?
lymphocytes
what is the diameter of a lymphocyte?
small: 7-10 micron range.

what is this?
lymphocyte

what are the arrows pointing to?
lymphocytes

what is this?
lymphocyte (small, mature)

what are the arrows pointing to?
lymphocytes

what is this showing?
infectious mononucleosis

what is this?
basophil
these WBCs have grains of histamine and heparin, are NOT phagocytic and normally are less than 1 per 100 in peripheral cells
basophil

what is this?
neutrophil
these prominent purplish and blue-black granules are associated with what?
Toxic granulation: prominent purplish and blue-black granules, associated with severe infxn and other toxic states.

what is this?
eosinophil
how do you identify an eosinophil?
Granulocytes characterized by acid stain eosin readily as pink/red granules.
what make up eosinophilic granules? what are they toxic to?
major basic protein & eosinophilic cationic protein. they are toxic to several parasites.

what is going on here?
eosinophilia

what is this?
monocyte

what is this?
classic horse-shoe shaped monocyte

what is this?
atypical monocyte

what is this?
monocyte

what's this? (arrow)
bone marrow: monoblast

what are these cells and when are they seen?
Plasma cells. Maybe seen in young children, viral infx, herpes, EBV. Not seen in peripheral blood of healthy adult.

what are the arrows pointing to?
macrocytes
when will you see macrocytes?
B12 and folate deficiencies

what are the arrows pointing at?
macrocytes
presence in the blood of erythrocytes with excessive variation in size
anisocytosis

identify these cells.
spherocytes

identify these rbcs
hypochromic microcytic

identify the rbc (arrow)
teardrop (dacrocyte)

identify this cell
target cell (codocyte)
when will you see a target cell?
Common in thalassemia, sickle-cell anemia, Hb-S thalassemia, other hemoglobinopathies

identify these cells
target cells

identify these cells and when are they seen?
ovalocytes/elliptocytes. A few is normal, but small #’s are seen in: iron deficiency, thalassemia, other hemoglobinopathies
thin elongated eythrocytes with a point at each end. Schistocytes of all types may be found. Found in Hb-S Thal and Sickle Cell.
Drepanocytes

identify these cells and when they are seen.
nucleated RBCs. Pernicious anemia & related B12-folic acid deficiency diseases. Usually see oval macrocytes and microcytes, and teardrops.

identify these cells
sickle cells/drepanocytes

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