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Glossary of Hypertension drugs

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Chlorothiazide
Thiazide
Hydrochlorothiazide
Thiazide
Chlorthalidone
Thiazide-like
Indapamide
Thiazide
Metolazone
Thiazide-like
Furosemide
Loop
Bumetadine
Loop
Torsemide
Loop
Ethacrynic acid
Loop (not sulfa)
Spironolactone
Potassium-sparing diuretic (aldosterone receptor blocker) Steroid-derived
Eplerenone
Potassium-sparing diuretic (aldosterone receptor blocker)
Amiloride
Potassium-sparing diuretic (Na channel blocker)
Triamterene
Potassium-sparing diuretic (Na channel blocker)
Mannitol
Osmotic diuretic
Urea
Osmotic diuretic
Sucrose
Osmotic diuretic
Glycerol
Osmotic diuretic
Nifedipine ER
Ca++ channel blocker. Greater selectivity for smooth muscle over cardiac. However lack of cardiac depressant effect leads to increased reflex tachycardia.
Verapamil, ER, SR
Ca++ channel blocker. Has cardiac depressant action causing less reflex tachycardia.
Diltiazem SR, ER
Ca++ channel blocker. Nonspecific antagonism.
Isradipine
Ca++ channel blocker. Approved for HTN only.
Captopril
ACEI. First nonpeptide ACE inhibitor. No intrinsic activity. May produce bone marrow depression.
Enalapril
ACEI. Prodrug metabolized to enaliprilat. 10-20x more potent than captopril. Does not contain sulfahydryl group.
Lisinopril
ACEI. A lysine derivative of enalipril
Benazepril, Fosinipril, Ramipril
ACEI. Lack sulfa group. Are prodrugs. Benazepril and ramipril are cleared mainly by kidney.

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