Hematology drugs
Terms
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- Name 4 antiplatelet drugs and their MOA
-
aspirin: inhibits CO dec. TXA2
clopidogrel: modifies ADP receptor
Ticlopidine: inhibits GPIIb/IIIa expression
Abciximab: binds GPIIb/IIIa -
Heparin MOA
lab? -
activates antithrobin III
(thus decreases thrombin and inactivates IXa-XIIa)
increase PTT - Heparin use
-
immediate anticoag
(pulmonary embolism, stroke, angina, MI, DVT) - What can you administer to reverse the heparin effects?
-
protamine sulfate
(binds neg. charged heparin) -
Low MX heparins
(enoxaprin)
(used in hip replacements)
MOA
advantages -
act more at Xa
longer half-life
subQ administration
do not have to monitor PTT -
Warfarin MOA (an oral agent)
lab? -
interferes w/ Vit K dep modification II, VII, IX, X, Protein C and S
follow PT - Warfarin use
- chronic anticoag
- How do you treat warfarin overdose
- IV of Vit K and fresh frozen plasma
- What drugs can increase the hepatic metab. of warfarin (3)
-
barbituates
glutethimide
rifampin -
what drugs can decrease the metabolism of warfarin (6)
IMPORTANT -
metronidazole
trimethoprim
disulfiram
cimetidine
phenylbutazone
sulfonamides
(influenza vaccine and acute alcohol intox) - Heparin or warfarin, which crosses the placenta?
-
warfarin
(it is teratogenic) - Name 4 thrombolytic agents and their use
-
streptokinase
anistrepelase (ASPAC)
atelplase (tPA)
urokinase
early MI -
Aminocaproic acid class
MOA -
fibrinolytic inhibitor
blocks plasmin biding to fibrinogen and fibrin -
Name the follwing hematopoeitic growth factors:
RBC
GM-CSF
C-CSF
macrophage (2) -
erythropoietin
Sargamostin (recombinant)
Filgrastim (recombinant)
Il-3 and M-CSF - Drugs hematology
- Drugs hematology