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Glossary of Hematology drugs

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Name 4 antiplatelet drugs and their MOA
aspirin: inhibits CO dec. TXA2
clopidogrel: modifies ADP receptor
Ticlopidine: inhibits GPIIb/IIIa expression
Abciximab: binds GPIIb/IIIa
Heparin MOA

lab?
activates antithrobin III
(thus decreases thrombin and inactivates IXa-XIIa)

increase PTT
Heparin use
immediate anticoag
(pulmonary embolism, stroke, angina, MI, DVT)
What can you administer to reverse the heparin effects?
protamine sulfate
(binds neg. charged heparin)
Low MX heparins
(enoxaprin)
(used in hip replacements)
MOA

advantages
act more at Xa


longer half-life
subQ administration
do not have to monitor PTT
Warfarin MOA (an oral agent)

lab?
interferes w/ Vit K dep modification II, VII, IX, X, Protein C and S

follow PT
Warfarin use
chronic anticoag
How do you treat warfarin overdose
IV of Vit K and fresh frozen plasma
What drugs can increase the hepatic metab. of warfarin (3)
barbituates
glutethimide
rifampin
what drugs can decrease the metabolism of warfarin (6)

IMPORTANT
metronidazole
trimethoprim
disulfiram
cimetidine
phenylbutazone
sulfonamides
(influenza vaccine and acute alcohol intox)
Heparin or warfarin, which crosses the placenta?
warfarin
(it is teratogenic)
Name 4 thrombolytic agents and their use
streptokinase
anistrepelase (ASPAC)
atelplase (tPA)
urokinase

early MI
Aminocaproic acid class

MOA
fibrinolytic inhibitor

blocks plasmin biding to fibrinogen and fibrin
Name the follwing hematopoeitic growth factors:
RBC
GM-CSF
C-CSF
macrophage (2)
erythropoietin
Sargamostin (recombinant)
Filgrastim (recombinant)
Il-3 and M-CSF
Drugs hematology
Drugs hematology

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