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Glossary of HPV

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History
Unknown; thought to be very ancient
Epidemiology
stats
–likelihood of acquiring some strain is 75-90%
Epidemiology
most common strain in women?
HPV-16
Epidemiology
Prevalence of genital warts
2%
Etiology
HPV family
Papovaviridae family - small DNA viruses
Etiology
Papilloma
benign growth= wart
Etiology
# of types?
>140
Etiology
cause common warts?
HPV 2, 4, 27, 29
Etiology
causes plantar warts
HPV 1
Etiology
cause flat warts
HPV 3, 10, 28, 49
Etiology
Genital strains?
many
Etiology
High risk strains
are found
in cervical and other genital tract cancers
Etiology
HPV-16, 18, 31, and 45
cause 80% of cervical cancer
Transmission
vectors:
shed cells are vectors of transmission
Transmission
Wound healing
causes rapid division of basal cells and may increase spread of HPV
Autoinnoculation may occur
Transmission
Oral transmission?
possible but not likely
Transmission
newborns during birth?
possible
Transmission
Condoms 100% safe against hpv?
no. lesions may occur in areas outside condom
Pathogenesis
Does virus go latent?
Yes, 1-8 months typically
Pathogenesis
Process
Virus in basal cells is replicated rapidly as cells rise to surface; cells at surface filled with viruses; organelles pushed to side
Pathogenesis
infection continues for ____ months until ________ response diminishes ________ load
3-6
immune
virus
Pathogenesis
Host ______ response determines whether disease ________ or _________
immune
progresses
regresses
Pathogenesis
Cancer is
uncontrolled cell growth
Pathogenesis
HPV proteins
fuck up the cells ability to regulate growth or commit suicide if cell is abnormal
Pathogenesis
HPV can hide...how do they?
ep______ial
frequently hides in epithelial cells that are not good at presenting antigens
Pathogenesis
Invasion of tissue leads to
transformation of cells
hence bad PAP smear
Pathogenesis
Invasive cervical cancer peaks after deep tissue invasion of HPV. Years?
15 years
Signs and Symptoms
Genital warts, condylomas, punched-out cells
Treatment and Prophylaxis
non genital warts are _________
Non genital warts are harmless
Treatment and Prophylaxis
one way that has been discovered to help remove warts...
Use of tape
Treatment and prophylaxis
ways to remove warts
surgical removal, cryosurgery, laser surgery, chemical treatment
Treatment and prophylaxis
Genital infection
–warts and condylomas may be removed; virus may continue indefinitely
Treatment and prophylaxis
vaccine
New Gardasil vaccine protects against four strains: 6, 11, 16, 18

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