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Glossary of Fungal Chemotherapy

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Amphoteracin B: mode of action
binds ergosterols (polyene antifungal)
Amphoteracin B: cidal or static
fungicidal
Amphoteracin B: targets
All systemic fungi (plus penicillium and fusarium?)
Nystatin: mode of action
another binds sterols (polyene antifungal)
Itraconazloe: mode of action
inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
Itaconazole: cidal or static
fungistatic
Itaconazole: targets
yeasts and molds- dermatophytes, dematiaceous moulds, systemic mycoses
voriconazole: mode of action
also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
Imidazole: mode of action
also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent) - toxic problems
Echinocandins: mode of action
Inhibits synthesis of B-(1,3)-glucans (cell wall)
Echinocandins: cidal or static
fungicidacl (Candida) & fungistatic (Aspergillus)
Echinocandins: targets
Candida, Aspergillus
Flucystosine: mode of action
Fluorinated pyrimidine analogue (DNA/RNA synthesis)
Flucosytosine: cidal or static
Fungistatic (must be used with other therapy)
Flucosytosine: target
Candida, Crytococcus
Terbinafine: mode of action
An allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene
Terbinafine: target
dermatomycoses (including onychomycosis) & sporotrichosis, aperfillosis, chromoblastomycosis
Terbinafine: cidal or static
fungistatic
Naftifine: mode of action
Another allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene (topical only)
Griseofulvin: mode of action
Disrupts microtubules (with side effects)
Griseofulvin: tragets
Dermatophytes (oral aplication)

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