Glossary of Factors in Extrinsic vs. Intrinsic Pathways:
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- What 3 factors activate the EXTRINSIC PATHWAY?
- 3, 4, and 7a
- What are factors 3/4/7?
- 3 = Tissue facot
4 = Calcium
7 = stabile factor
- What do Fx 3/4/7a do together?
- Activate X -> Xa
- Along with activating X-Xa what can VIIa activate?
- IX to IXa in the intrinsic pathway.
- What test monitors the extrinsic pathway?
- Protime (PT)
- What activates Fx XII?
- Contact factors on platelet surfaces.
- What helps Fx XIIa convert XI -> XIa?
- What helps Fx XIa convert IX to IXa?
- What helps Fx IXa start the common pathway?
-PF3 (just a phospholipid)
- What test is used to evaluate the intrinsic pathway?
- the APTT.
- what initiates the COMMON pathway?
- Activation of Fx X by
- What does Factor Xa do?
- Actvts Prothrombin->Thrombin with helpers Ca2+, PF3, Va.
- What factor is thrombin?
- Fx II
- What does Thrombin (factor 2)activate?
- -V (feedback)
-Fibrinogen -> Fibrin
-XIII -> XIIIa
- What is the role of Plasmin?
- Fibrinolysis - Breaks down fibrin clots
- What activates plasminogen?
- 1. t-PA (tissue plasminogen activator)
- What are the reagents for the Protime?
--> rapid fibrin clot formatn
- What are the reagents for the aPTT?
- -Phospholipid substitute
--> slower clot formation.
- What factors does the PT test measure?
- I II V VII X
- What will cause a prolonged PT?
- -Coumadin therapy
-Deficient Factors 1/2/5/7/10
-Vit K deficiency/defect
- What factors does the APTT measure?
- 1,2,5,8,10,11,12, Fletcher, Fitzgerald.
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