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Glossary of FA page 199 G-protein linked 2nd messengers, major functions plus major grouping

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What is the major function of alpha 1 receptors?
increase vascular smooth muscle contraction
What are the major functions (2) of alpha 2 receptors?
1. decrease sympathetic outflow
2. decrease insulin release
What are the major functions (5) of beta 1 receptors?
1. increase HR
2. increase contractility
3. increase renin release
4. increase lipolysis
5. increase aqueous humor formation
What are the major functions (3) of beta 2 receptors?
1. vasodilation
2. bronchodilation
3. increase glucagon release
What is the major function of M1 receptors?
CNS
What is the major function of M2 receptors?
decrease HR
What is the major function of M3 receptors?
increase exocrine gland secretions
What is the major function of D1 receptors?
relaxes renal vascular smooth muscle
What is the major function of D2 receptors?
modulates transmitter release, especially in brain
What are the major functions (4) of H1 receptors?
1. increase nasal and bronchial mucus production
2. contraction of bronchioles
3. pruritis
4. pain
What is the major function of H2 receptors?
increase gastric acid secretion
What is the major function of V1 receptors?
increase vascular smooth muscle contraction
What is the major function of V2 receptors?
increase water permeability and reabsorption in the collecting tubules of the kidney
5 receptors involving Gq?
"H.A.V.M.M":
1. H1
2. alpha1
3. V1
4. M1
5. M3 (unique in this group)
What happens when a substrate binds to a Gq receptor?
Gq--> PLC--> lipids cleaved --> PIP2 -->*IP3--> increase Ca
(and) -->*DAG--> PKC

* = branch point
What are the groups of receptors (5) involving Gs?
"B.V.H. B.D.":

1. beta 2
2. V2
3. H2
4. beta 1 (unique in group)
5. D1 (unique in group)
What happens after a substrate binds to the Gs receptor?
Gs--> adenylcyclase --> ATP --> cAMP --> INCREASE
PKA
What happens after a substrate binds to the Gi receptor?
Gi--> adenylcyclase --> DECREASE cAMP --> DECREASE PKA
What are the groups of receptors (3) involving Gi?
"A.M.D.":

1. alpha 2
2. M2
3. D2

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