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Glossary of FA Pharmacology: ANS Drugs

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Epineprhine: Selectivity and Clinical Application?
cathecholamine

direct general agonist(a1,a2,B1,B2)

anaphylaxis, glaucoma (open angle), asthma, hypotension
Norepinephrine: Selectivity and Clinical Application?
catecholamine

a1, a2, B1

Hypotension, (but decreases renal perfusion)
Isoproterenol: Selectivity and Clinical Application?
catecholamine
B1 = B2

AV block(rare)
Dopamine: Selectivity and Clinical Application?
catecholamine
D1=D2 >B >a

Shock (increases renal perfusion), heart failure
Dobutamine: Selectivity and Clinical Application?
catecholamine
B1 >B2

shock, heart failure
Amphetamine: mechanism and clinical application?
indirect general agonist, release stored catecholamines

Narcolepsy, obesity, ADHD
Ephedrine: mechanism and clinical application?
indirect general agonist, releases stored catecholamines

nasal decongestant, urinary incontinence, hypotension
Phenylephrine: selectivity and clinical application?
a1 >a2

pupil dilator, vasonconstriction, nasal decongestion
Albuterol
Terbutaline

...selectivity and clinical application?
B2>B1

asthma
Cocaine: mechanism and clinical application?
indirect general agonist; uptake inhibitor

causes vasoconstriction and local anesthesia
Clonidine: mechanism and clinical application?
Centrally acting a-agonist, decreases central adrenergic flow

Hypertension, especially with renal disease (no decrease in blood flow to the kidney)

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