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Glossary of FA Immunology 186

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What cytokines are secreted by Th cells?
IL-2,4,5,6, gamma-IFN
What cytokines are secreted by Macrophages?
IL-1, TNF-alpha, IL6,IL12
What cytokines are secreted by activated T cells (not specified)?
IL-3
What cytokines are secreted by B cells?
IL-12
What cytokines are secreted by Th2 (specifically)?
IL-10
In general, what are the functions of IL1-5?
Hot T-Bone stEAk
IL-1: Fever
IL-2: T cells
IL-3: Bone marrow
IL-4: IgE
IL-5: IgA
Stimulates T cells, B cells, neutrophils, fibroblasts, and epithelial cells; an endogenous pyrogen
IL-1 (macrophages)
Stimulates growth of Th and Tc cells
IL-2 (Th)
Supports the growth and differentiation of bone marrow stem cells (like GM-CSF)
IL-3 (activated T cells)
Promotes growth of B cells. Enhances class switching of IgE and IgG
IL-4 (Th)
Promotes differentiation of B cells. Enhances class switching of IgA. stimulates production and activation of eosinophils.
IL-5 (Th)
Stimulates production of acute-phase reactants and Igs
IL-6 (Th, Macrophages)
Major chemotactic factor for neutrophils
IL-8 (none listed)
Stimulates Th2 while inhibiting Th1
IL-10 (Th2)
Activates NK cells and Th1 cells
IL-12 (B cells and Macrophages)
Stimulates macrophages.
gamma-interferon (Th)
Inc IL-2 receptor synthesis by Th cells
Inc B cell proliferation
Attracts and activates PMNs
stimulates dendritic cell migration to LN
TNF-alpha (Macrophages)

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