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Glossary of Endocrine High Yield LM Review Step 1 USMLE

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What drug causes Prolactinoma?
Haloperidol (Haldol)
What causes prolactinoma?
decrease in dopa
Tx of prolactinoma?
Bromocriptine
What is the S/E of Levodopa?
psychoses, hallucinations, hypotension, dyskinesia

go crazy w/ DOPA INCREASED!
What is bromocriptine? Acts on?
Dopamine Agonist D2 receptor agonist
What drug enhances levodopa effects?
Tolcapone and Entacapone

Alcopone Protects levodopa
WHat is the effect of Tolcapone and Entacapone?
AAAD inhibited
more dopa is converted by COMPT to 3-o-methyldopa

also inhibit peripheral COMT to prevent L-dopa degradation
What is the A/E of tolcapone?
Hepatotoxic
DOPA low dose? what are the effects?
alpha and beta agonist
adrenergic receptors activated

lower dose activates B1 cardiac receptors activated
increase heart rate
What are the effects of DOPA at high dose?
Vasoconstriction by activating alpha receptors

D1 + D2 Renal = Vasodilation
Patient post-surgery w/ high fever Tx?
Dantrolene'

pat. w/ malignant hyperthermia
Neuroleptic Malignant Syndrome is tx with?
Dantrolene and Bromocriptine (DA agonist)

BOTH!!!
Agranulositosis pat?
caused by Carba, Colchicine, and Clozapine
What are the antipyschotics?
haloperidol
chlorpromazine
thioridazine
fluphenazine
What are the atypical antipsychotics?
Clozapine
Risepridone
Olanzapine

Ola says the Clown and risas...
Toxicity of Antipsychotics?
OD w/ M block, alpha block
sedation
decrease in seizure threshold
Antipsychotic that causes Tosade?
Thioridazine
A/E of Thioridazine?
Cardiotoxic (torsade)
retinal deposits
M block
Alpha Block
A/E of chlorpromazine?
ocular dysfunction
M block
Alpha Block
What two antipsychotic cause EPS? (extra pyramidal symptoms)?
Haloperidol
Fluphenazine
New antipsychotic that works on both D2 receptor agonist and blocks 5HT2 receptors?
Ari piprazole

almost no side effects
no EPS, no M block, no alpha block
no sedation
What are the antipsychotics that cause the most sedation?
Chlorpromazine
Thioridazine
What is tardive dyskinesia?
Choreoathethetoid muscle movements
dance like and snake like movements

mostly the typical antipsychotics cause this
DOC for Tourette Sx? or Huntington's Dz

Coprolalia
Pimozide
Antipsychotic
What is promethazine used for?
Preoperative sedation
Drug/Radiation Emesis prevention?
Prochlorperazine
What gene is Rb gene found?
chromos. 13
What pathology is seen in Rb?
Retinoblastoma
Osteosarcoma

add the letters/2=13
What is the mechanism of action of dantrolene?
acts on the sarcoplasmic reticulum, prevents Ca+ release

muscle antispasmodic
What chromosome contains BRCA1 & 2?
17q, 13q-
What does BRCA cause?
Breast and ovarian CA
What chromosome contains p53?
17q
What chromosome contains p16?
9p
What disease is caused by p16 gene?
Melanoma
What chromosome is gene APC located?
5p
What does APC gene code for?
Colorectal CA
What chromosome is WT-1 located in?
11q
What does WT-1 gene cause?
Wilm's Tumor
What gchromo is NF-1 gene located in?
17q
What cancer is caused by NF-1 gene?
Neurofibromatosis 1
What chromo is NF-2 gene located in?
22q
What chromo. is DPC located in?
18q
What does DPC cause?
pancreatic CA
What chromo. is DCC?
18q
What does DCC predispose to?
Colon CA
When do you see Psammoma bodies?
Papillary (thyroid) Serous (ovary, Meningioma, Mesothelioma
Squamous cell CA produced by?
Sun Exposure

Arsenic
Squamous Lung Cell Ca secrete?
Hypercalcemia?
Calcium Stone Formers

PTH-like peptide
PTH-like related peptide causing hypecalcemia?
Squamous Cell Lung CA
Renal Cell CA
Breast CA
Multiple Myeloma
Bone Metastasis
Renal Cell CA
Hemangioblastoma produce?
Erythropoietin

Polycythemia
Thymoma
Small Cell Lung CA produce what exogenously?
causes Ab to presynaptic Ca+ at neuromuscular junction

Lambert-Eaton Sx

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