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Glossary of Eicosanoids

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PAF is liberated by PLA2. What are the effects of PAF
activates & aggreates platelets
vasodilation
up vascular permeability
chemotaxis of PMLs
bronchospasm (asthma)
brocho hyperresponsiveness
Actions of TXA2
platelet aggregation
PGI2
anatagonist to TXA2
relax bronchioles
vasodilates cardiac sys
hypotension
cause pain
inhibt acid secretion, up mucus
PGE2
uterine contraction
patent ducturs arteriosis
vasodilator
inhibit effect of ADH (stops holding water, for hypertension)
cause pain
stomach protection
PGF2a
uterine contraction
bronch contraction
constriction pulm arteriers
PGD2
contract bronchial SM
dilate cardiac sys at low conc, constrict at high
Leukotriens
most potent bronciol constrictor
caues pain
induce migration of inflammatory processes
cause uterine contraction
PGE and PGF
vasodilators
PGI, PGE and PGD (low conc.)
GI protection
PGE and PGI
platelet aggregation
TXA
bronchiol constrction
PGF, PGD, LT's
vasodilation to kidneys
PGs
cause pain
PGE, PGI, LT's
agonist for PGF2
carboprost

uterine contraction
agaonsist of PGE2
dinoprostone

used for uterine contraction
agonist for PGE1
misoprostol

protects stomach with NSAIDS, dont use if pregnant (why?)
Where is PGF made?
Uterus
Where is PGE expressed
blood vessels, kidney, skin, lungs, brain
add this to NSAID tx to protect gastric mucosa
Misoprostil

Increase mucous production to protect stomach

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