Drug Class - Lipid-Lowering Agents
Terms
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- Name 3 lipid-lowering agents?
-
bile acid sequestrants
HMG-CoA reductase inhibitors
miscellaneous - Name 3 bile acid sequestrants?
-
cholestyramine
colesevelam
colestipol - Name 6 HMG-CoA reductase inhibitors?
-
atorvastatin
fluvastatin
lovastatin
pravastatin
rosuvastatin
simvastatin - Name 5 miscellaneous lipid-lowering agents?
-
ezetimibe
fenofibrate
gemfibrozil
niacin
niacinamide - Lipid-lowering agents are used as a part of a total plan including diet and exercise to reduce blood lipids in an effort to reduce morbidity and mortality of _________ cardiovascular disease and its _______.
-
atherosclerotic
sequelae -
Vytorin or
generic name ezetimibe/simvastatin is a
new (July 2006) combination medication on the market that doctors are using in place of? -
Lipitor (newspaper)
manufactured for
Merck/Schering-Plough Pharm. - Which group of lipid-lowering agents inhibit an enzyme involved in cholesterol synthesis?
- HMG-CoA reductase inhibitors
- Which group of lipid-lowering agents bind cholesterol in the GI tract?
- bile acid sequestrants
- The miscellaneous lipid-lowering agents act by other mechanisms and are separated in individual monographs.
- okay
- Contraindications?
- hypersensitivity
-
Precautions?
Safety in pregnancy, lactation, and children not established. See individual drugs. Dietary therapy should be given a ___ to ____ month trial before drug therapy is initiated. - 2-3
-
Interactions?
Bile acid sequestrants (cholestyramine and colestipol) may bind ____-____ vitamins (A,D,E, and K)
and other concurrently administered drugs in the GI tract. The risk of myopathy from ______ reductase inhibitors is increased by nia - lipid-soluble
- When assessing for use of lipid-lowering agents, obtain a diet history, especially in regard to ____ and ____ consumption.
-
fat
alcohol - When assessing for use of lipid-lowering agents, lab tests that should be considered before initiating and periodically throughout therapy are?
-
serum cholesterol levels
triglyceride levels
(medication should be discontinued if paradoxical increase in cholesterol occurs) - When assessing for use of lipid-lowering agents, ____ function tests should be assessed before and periodically throughout therapy. May cause an increase in levels.
- liver
- Two potential nursing diagnoses are?
-
Knowledge, deficient, related to disease processes and medication regimen
Noncompliance -
IMPLEMENTATION:
See specific medications to determine ____ of doses in relation to ____. -
timing
meals - Advise patient that these medications should be used in conjunction with diet restrictions which include?
-
fat
cholesterol
carbohydrates
alcohol
(also teach patient about exercise and smoking cessation) -
EVALUATION:
Effectiveness of therapy can be demonstrated by? - decreased serum triglyceride and LDL cholesterol levels and improved HDL cholesterol ratios. Therapy is usually discontinued if the clinical response is not evident after 3 months of therapy.