Glossary of Comparitive Physiology 2

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annelids are fond of respiratory pigments. thye live in low O2 environments and need lots of pigments.
Phylogenetic Distribution of Respiratory pigments
conclusions: hemoglobins are very old molecules
annelids have many resp. pigments.
4 heme groups (2 alpha, 2 beta). each heme group has iron molecule in its center.
Difference between oxyhemoglobin and deoxyhemoglobin?
OXY--> red, HbO2
DEOXY--> blue, Hb
Predecessors of Hemoglobin
Probably served a diferent function other than O2 transport. Know this b/c some organisms have hemoglobin that don't need it, function may have been electron transport
allosteric effect
the bonding of one O2 molecule effects the ability of the molecule to accept more O2. hard to seek polypeptides w/out O2, but once O2 is present it's eaier to load more O2
Bohr Effect
-more H+ pushes towards an unloading curve (% saturation of O2 decreases)
-less H+ pushes towards a loading curve
myoglobin is a resevoir of O2 in the muscle so it's reluctant to give off O2. increased % saturation of O2. shifted towards loading curve.
Hemoglobin S
sickle-cell anemia....polymerizes when it gives up O2 -- causes cell to sickle. prone to giving up O2. shifted toward an unloading curve.
How is CO2 carried in the blood?
70% bicarbonate ions
Super Nitric Oxide -- the newest function of hemoglobin
Hemoglobin picks up super NO (NO w/ an extra electron). Hemoglobin relases O2 and superNO at the tissues. superNO causes vasodilation of blood vessels to increase the amound of oxygen-carrying blood to that tissue.

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