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Glossary of Coag factor nomenclature

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Factor I
Fibrinogen
Factor II
Prothrombin
Factor III
Tissue thromboplastin (Tissue Factor)
Factor IV
Ionized Calcium
Factor V
Labile factor
Factor VI
Doesn't exist!
Factor VII
Stabile factor
Factor VIII
-Anti-hemophiliac factor AHF
-VIII:C (oagulant portion)
Factor IX
-Chrismas factor
-AHFb
Factor X
Stuart-Prower factor
Factor XI
PTA --> plasma thromboplastin antecedent
Factor XII
Hageman factor
-contact factor
Factor XIII
Fibrin-stabilizing factor
Fitzgerald factor
HMWKininogen
Fletcher factor
prekallikrein
Which factor is a Substrate factor?
Fibrinogen
Which factor is a Cofactor?
5-Labile factor
8-Factor VIII:C
Which factors are Enzymes?
Many:
IIa, VIIa, IXa, Xa, XIa, XIIa, prekallikrein
Which factors are serine proteases?
Any of the enzymes that have been activated.
Which factor is a transaminase?
Factor XIII
What are the 2 ways to classify coagulation factors?
1. By hemostatic function (above)
2. By physical properties
What are the 3 groups of factors based on phys. property?
1. Contact proteins
2. Prothrombin proteins
3. Fibrinogen/thrombin sensitive proteins.
What 4 factors are Contact proteins?
1. Prekallikrein
2. HMWK
3. Fx XII
4. Fx XI
What types of hemostasis problems assoc. w/ Deficient
-F XI
-Hageman/Fletcher
Factor XI = mild bleeding

Factors XII/Prekallikrein = thrombosis
What is in the prothrombin group?
Low-molecular wght proteins:
II, VII, IX, X
2, 7, 9, 10
What's another name for the prothrombin group?
Vit-K dependent group.
What makes the Vit-K group unique?
Gamma-carboxyglutamic acid - necessary for binding to platelets and Ca2+ binding.
What acts as an antagonist to vitamin K?
Warfarin - Coumadin.
Why is the extrinsic pathway called extrinsic?
B/c Tissue Factor (its phospholipid activates cascade) isnt normally in circulation.
Where are the necess phospho-lipids for intrinsic pathway?
In platelet membranes.

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