Glossary of Coag factor nomenclature
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- Factor I
- Factor II
- Factor III
- Tissue thromboplastin (Tissue Factor)
- Factor IV
- Ionized Calcium
- Factor V
- Labile factor
- Factor VI
- Doesn't exist!
- Factor VII
- Stabile factor
- Factor VIII
- -Anti-hemophiliac factor AHF
-VIII:C (oagulant portion)
- Factor IX
- -Chrismas factor
- Factor X
- Stuart-Prower factor
- Factor XI
- PTA --> plasma thromboplastin antecedent
- Factor XII
- Hageman factor
- Factor XIII
- Fibrin-stabilizing factor
- Fitzgerald factor
- Fletcher factor
- Which factor is a Substrate factor?
- Which factor is a Cofactor?
- 5-Labile factor
- Which factors are Enzymes?
IIa, VIIa, IXa, Xa, XIa, XIIa, prekallikrein
- Which factors are serine proteases?
- Any of the enzymes that have been activated.
- Which factor is a transaminase?
- Factor XIII
- What are the 2 ways to classify coagulation factors?
- 1. By hemostatic function (above)
2. By physical properties
- What are the 3 groups of factors based on phys. property?
- 1. Contact proteins
2. Prothrombin proteins
3. Fibrinogen/thrombin sensitive proteins.
- What 4 factors are Contact proteins?
- 1. Prekallikrein
3. Fx XII
4. Fx XI
- What types of hemostasis problems assoc. w/ Deficient
- Factor XI = mild bleeding
Factors XII/Prekallikrein = thrombosis
- What is in the prothrombin group?
- Low-molecular wght proteins:
II, VII, IX, X
2, 7, 9, 10
- What's another name for the prothrombin group?
- Vit-K dependent group.
- What makes the Vit-K group unique?
- Gamma-carboxyglutamic acid - necessary for binding to platelets and Ca2+ binding.
- What acts as an antagonist to vitamin K?
- Warfarin - Coumadin.
- Why is the extrinsic pathway called extrinsic?
- B/c Tissue Factor (its phospholipid activates cascade) isnt normally in circulation.
- Where are the necess phospho-lipids for intrinsic pathway?
- In platelet membranes.
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