Glossary of Coag II
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- For diagnosing bleeding disorders, what are the:
- Screen: PT/PTT/BT/Plt count
Confirm: plt aggregation, factor assay
- What generalized systemic defects can cause prolonged pt/ptts?
- -Liver disease
-Chronic cancer, etc.
- How can bleeding symptoms differentiate Platelet vs. Coag factor deficiencies?
- Petichiae = PLATELETS, not coag factor.
-Also has spontaneous mucous membrane bleeding.
- What's more common; acquired or hereditary coagulopathies?
- What causes acquired coagulopathies?
- Aspirin, drugs, autoimmune disease, etc.
- What bleeding disorders are sex-linked recessive?
- -Hemophilia A/B
- How can the PT/PTT diff. btwn platelet/vasc disorders and Coagulation disorders?
- Platelet/vascular: PT/PTT are NORMAL
Coag: abnormal - prolonged
- How does the BT differentiate them?
- BT is elevated in Plt/vasc, not in Coag factor deficiency.
- What 3 tests are used to diagnose platelet diseases?
- -Platelet aggregation
- For coagulation defects:
-What are the screens?
-What are the diagnostic tests?
- Screens: PT/PTT
Confirm: Electrophoresis, factor assays, genetic studies.
- What type of abnormality will show HEMARTHROSES?
- Coag defects; not platelet.
- How does NORMAL PLASMA correct a prolonged PT/PTT?
- -Replaces 50% of all factors!
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