Glossary of Clerkship - Neuro - Movement Disorders (blueprints)
Other Decks By This User
- 4 Cardinal Features of Idiopathic Parkinsons
- tremor, rigidity, bradykinesia, postural instability
- 5 Parkinsonian Syndromes
- Progressive Supranuclear Palsy
Corticobasal Ganglionic Degeneration
Diffuse Lewy Body Disease
Multiple Systems Atrophy
- Supranuclear opthalmoplegia, with limitation of vertical more than horizontal gaze; axial rigidity and neck extension early falls as a consequence of imparied postural reflexes, neck extension, and inability to look down
- Progessive Supranuclear Palsy
- Apraxia, cortical sensory impairment and alien-limb phenomenon; severe unilateral rigidity; stimulus-sensative myoclonus
- Corticobasal Ganglionic Degeneration
- Early dementia
Prominant visual hallucinations
Extreme sensativity to extrapyramidal side-effects of antidopaminergic neuroleptic drugs
- Diffuse Lewy Body Disease
- "Lower-half" parkinsonism with rigidity in legs and marked gait impairment; other evidence of diffuse vascular disease (corticospinal tract dysfunction, pseudobulbar palsy)
- Vascular Parkinsonism
- Early and prominent features of autonomic dysfunction
Evidence of corticospinal tract dysfunction
Vocal cord paresis
- Multiple systems atrophy
- The tremor in Idiopathic Parkinsons is fast/slow?
and more prominant when limb is at rest/in motion?
worst when limb is at rest
- Dementia or delerium is seen in Parkinsons?
- Dementia in 1/3 of pts
- What is the name of L-Dopa + Carbidopa?
- Sinemet. Carbidopa inhibits peripheral decarboxylase (preventing dopamine formation outside the CNS)
- What is selegeline?
- monoamine oxidase B inhibitor
- Muscular rigidity, fever, autonomic lability, altered level of consciousness, elevated creatine kinase level, leukocytosis
- Neuroleptic Malignant Syndrome (NMS) <-- drugs with dopamine receptor-blocking activity
- Neuroleptic Malignant Syndrome (NMS)
- Muscular rigidity, fever, autonomic lability, altered level of consciousness, elevated creatine kinase level, leukocytosis <-- drugs with dopamine receptor-blocking activity (neuroleptics)
- What is Akathisia?
- an dysphoric state characterized by the subjective desire to be in constant motion <-- drugs with dopamine receptor-blocking activity
Anticholinergics and Beta blockers can be used to treat this
- symptoms of Tardive Dyskinesia
- Orolinguomasticatory dyskenisia <-- drugs with dopamine receptor-blocking activity (neuroleptics)
Sx: chewing movements, lip smacking, rolling of the tongue inside the cheek.
Tx: discontinue affecting agent. Dopamine depleting agents (reserpine, tetrabenzine) may help
- Name 2 anticholinergics for Parkinsons Tx
Benztropin (Michael J Fox driving a Benz)
Side Effects: Dry mouth, constipation, urinary retention, confusion, hallucination, narrow-angle glaucoma
- Name an NMDA antagonist for Parkinsons Tx
- Name 4 Dopamine agonists for Parkinsons Tx
Side effects: Nausea, orthostatic hypotension, psychosis, hallucinations, dyskinesia (Same as Levodopa/Carbidopa)
- Name 2 COMT inhibitors for Parkinsons Tx
similar side effects to levodopa/carbidopa and dopamine agonists.
Nausea, orthostatic hypotension, confusion, dyskinesia
- Mechanism of levodopa/carbidopa
- Dopamine precursor/dopa decarboxylase inhibitor
Side effects: anorexia, nausea, psychosis, hallucinations, orthostatic hypotension, dyskinesia
- chonic axial muscle rigidity and stiffness and painful muscle spasms
- Stiff-person syndrome
- What antibody is associated with Stiff-person syndrome?
- Anti-GAD antibodies
"chonic axial muscle rigidity and stiffness and painful muscle spasms"
- Causes of resting tremor
- Parkinson's Disease
- Causes of postural tremor
- (emerges during sustained maintenance of posture)
Drugs (eg. theophylline, beta-agonists)
- Causes of action tremor
- Cerebellum and cerebellar outflow tract dysfunction (e.g. infarction, multiple sclerosis, tumor, Wilson's disease, drugs)
- what is intention tremor?
- a tremor that increases as the target is approached
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