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Glossary of Chapter 17 Antiadrenergic Drugs

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What is the effect of alpha or beta stimulation in the CNS, peripheral postsynaptically or peripheral presynaptically?
CNS Beta 2 - inhibits SNS -VD;
PPost - alpha 2 VC, Beta 2 VD;
PPre - Beta increase NEpi, alpha 2 decrease NEpi;
Central Adrenergic Inhibitors (alpha 2 agonists) have what effect on the Sympathetic outflow from the medulla?
Diminished outflow leading to decrease BP and HR.
What condition is Alpha 2 agonists indicated?
HTN, but not CHF because not potent enough Vasodilator.
What are the side effects in Alpha 2 agonists?
Sedation, dry mouth, bradycardia
What is the mechanism of action of the sympathetic nerve ending antagonists, guanethidine and guanedrel?
These drugs are taken up by the NE uptake pump and then by the synaptic vesicles. Here, they prevent the synaptic release of NE.
What is the mechanism of action of the sympathetic nerve ending antagonist, reserpine?
Reserpine inhibit NE synaptic vesicle uptake.
In what condition is reserpine contraindicated?
History of depression
Alpha 2 Receptor feedback inhibition blockade results in what? So name (3) Alpha 1 selective antagonists and what they condition they treat.
Greater Reflex Tachycardia; Prazosin, Terazosin and Doxazosin all treat HTN while T & D treat BPH.
The nonselective alpha blockers, phentolamine and phenoxybenzamine, are used in treating what condition?
Pheochromocytoma (tumor that abnormally secretes catecholamines)
Beta adrenergic Receptor Antagonists are indicated in what conditions?
IHD, HTN, CHF, Tachy-Arrhythmias
What are the effects of Beta adrenergic Receptor Antagonists?
Decreased inotropy, chronotropy, and conduction velocity.
Toxicities such as AV node blockade, bronchospasm,, arterial vasospasm, or hypoglycemia can be related to what 3 adrenergic drug differences?
Relative selectivity for specific subtypes of Beta 1 or 2; ISA activity; concomitant effect on alpha receptors
TRUE/FALSE - Abrupt withdrawal of a Beta blocker can cause an Acute Myocardial Infarction in patients with underlying CAD.
True
Toxicities of Beta blockers can cause AV node block, bronchospasm,reduction of HDL, arterial vasospasm, or hypoglycemia recovery. What 3 receptor differences account for this?
Relative selectivity for specific subtypes of Beta 1 or 2; ISA activity; concomitant effect on alpha receptors

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