Glossary of Ch. 10: Haemophilus, Bordetella and Legionella
Other Decks By This User
- How do you treat gardnerella vaginalis (formerly haemophilus vaginalis)?
- How can you tell gardnerella vaginalis from candida or trichomonas?
- clue cells: vaginal epithelial cells w/ tiny pleomorphic bacilli within the cytoplasm
- What causes bacterial vaginitis in conjunction with anaerobic vaginal bacteria?
- gardnerella vaginalis
- How do you treat chancroid?
- erythromycin or trimethoprim/sulfamethoxazole
- What are 3 differentials when ruling our chancroid?
- 1. syphilis (treponema pallidum); 2. herpes (simplex virus 1 & 2); 3. lymphogranuloma venereum (LGV: chlamydia trachomatis)
- What causes chancroid? What are the signs?
- 1. haemophilus ducreyi; 2. painful genital ulcer, unilateral painful inguinal lymph nodes
- What type of vaccine is used against h. influenza?
- combo of H. influenza capsule + diphteria toxin (diphteria toxin activates T-lymphocytes)
- What are 3 gram - rods acquired through the respiratory tract?
- haemophilus influenza, bordetella pertussis, legionella pneumophila
- What diseases are caused by h. influenzae?
- 1. meningitis; 2. acute epiglottitis; 3. septic arthritis; 4. sepsis
- What makes the h. influenza virulent?
- 1. b capsule (polysaccharide); 2. kids aged 6mos to 3yrs don't make antibodies against the b capsule
- In what medium does h.influenza grow?
- blood-containing medium; needs hematin and NAD+
- Who is susceptible to h. influenza infection?
- people weakened by viral lung infection, people without spleen
- What is the mechanism of bordetella pertussis? What disease does it cause?
- 1. attaches to ciliated epithelial cells of trachea and bronchi; 2. whoopinig cough
- What are the 4 exotoxin weapons of bordetella pertussis?
- 1. pertussis toxin A + B (Bind and Action); 2. extra cytoplasmic adenylate cyclase; 3. filamentous hemagglutinin (FHA); 4. tracheal cytotoxin
- What is the role of adenylate cyclase & cAMP in bordetella pertussis?
- AC increases cAMP, leading to impaired chemotaxis, impaired generation of H202 and superoxide, leading to decreased phagocytosis and bacterial clearance
- What does the FHA (filamentous hemagglutinin) in bordetella pertussis do?
- allows binding to ciliated epithelial cells of bronchi
- What does the tracheal cytotoxin in b. pertussis do?
- helps destroy the ciliated epithelial cells
- Is whooping cough contagious?
- What are the 3 stages of whooping cough?
- 1. catarrhal stage; 2. paroxysmal stage; 3. convalescent stage
- How do you culture suspected b. pertussis?
- 1. calcium alginate swab; 2. grow on Bordet-Gengou medium (potato + blood agar)
- What is the treatment for whooping cough?
- primarily supportive therapy; erythromycin in the predromal or catarrhal stage to prevent the disease
- What is the vaccine against whooping cough?
- part of the DPT vaccine (diphteria, pertussis, tetanus); made of pertussis toxin, FHA, adenylate cyclase
- Where do you find legionella pneumophilia?
- in natural and manmade water environments
- What is the main mechanism of legionella pneumophilia?
- intracellular parasite that settles in the lower resp tract and taken in by macrophages; inhibits phagosome-lysosome fusion
- What are 2 diseases caused by legionella pneumophilia?
- 1. pontiac fever (mild flu-like symptoms); 2. Legionnaires' disease (pneumonia in people 50+ years, esp. with smokers)
- What is the treatment of legionella pneumophila infection?
You must Login or Register to add cards