Glossary of Caenorhabditis elegans (Nematode) Developmental Biology
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- Early technique for studying genetics of C. elegans
- What are the three axes which form during development?
- 1) Anterior-Posterior
- What is the term for the development from zygote through organogenesis?
- Which animal is good for developmental studies, but not genetic studies because it is difficult to raise many generations in the lab?
- Sea Urchin
- What is the total number of cells in the first larva stage of C. elegans?
- Five hundred and fifty-eight (558)
- What is the number of somatic cells in the adult of C. elegans?
- Nine hundred and fifty-nine (959)
- What's a three-word term explaining C. elegans' unchanging fate of each cell?
- invariant cell lineage
- From the two-cell to the four-cell stage, which two daughter cells come from the AB cell?
- AB.a (anterior)
- From the two-cell to four-cell stage, which two cells come from the P1 cell?
EMS (another founder cell)
- What's the type of cleavage exhibited by C. elegans?
- rotational holoblastic cleavage
- What does Hoescht blue dye bind to?
- In the wild type, into what cells do the P-granules migrate?
- P cells
- Localization of P-granules requires _____________ rather than microtubules.
- What is used to cause the par-(1-4) mutants?
- A temperature increase to 25˚ C.
- At the four-cell stage, the AB.p cell defines the future ______ side, while the EMS cell defines the future _______ side of the embryo.
- dorsal, ventral
- At the twelve-cell stage, the MS blastomere with AB.a descendant cells defines the _____ side of the embryos.
- SKN-1 is a _____________ ______.
- transcription factor
- Mutations in skn-1 result in both EMS descendants developing into additional _ founder cells.
- PIE-1 inhibits _____ function in the P2, resulting in the P2 adopting _______ fate.
- SKN-1, somatic
- Mutations in mex-1 make all four AB granddaughter cells convert into extra __ fate, developing extra __________ and ______ cells in the anterior.
- MS, pharyngeal, muscle
- Only recombination of the early isolated EMS cells with __ restuores the ability to form gut cells.
- At the four-cells stage, the P2 produces a signaling molecule, MOM-2, the C. elegans homologue of a ___ protein.
- MOM stands for ____ ________.
- more mesoderm
- The EMS cell produces a receptor protein, _____, the C. elegans homologue of the Wnt receptor, Frizzled.
- The binding of MOM-2 from the P2 to the MOM-5 in the EMS instructs the EMS to divide into the _ cell (________ giving rise to the gut) and the __ cell (________ giving rise to the muscles).
- E, endoderm, MS, mesoderm
- APX stands for ________ _______ ______.
- anterior pharynx excess
- P2 also produces APX-1, the C. elegans homologue of the _____ proteins (ligant).
- Both AB.p and AB.a cells produce GLP-1, the C. elegans homologue of the _____ proteins (receptor).
- The binding of APX-1 from the P2 cell to the _____ in either AB.p or AB.a makes it develop into the ______ side of the embryo.
- GLP-1, dorsal
- GLP stands for ____ ____ _____________.
- germ line proliferation
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