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Glossary of Block 4: Antibiotics- misc

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drugs that inhibit growth of a pathogen without causing cell death
bacteriostatic
drugs that kill bacteria
bactericidal
lowest concentration of the drug that inhibits visible growth after 18-24 h of incubation IN VITRO
minimum inhibitory concentration (MIC)
lowest concentration of drug at which 99.9% of a culture is killed after 18-24 h incubation IN VITRO
minimum bactericidal concentration (MBC)
when suppression of bacterial growth continues after the antibiotic concentration falls below the bacterial MIC
post-antibacterial effect (PAE)
bactericidal effects increase with increased concentration of antibiotic
concentration-dependent killing
bactericidal effects occur only during the time when the antibiotic is maintained above the MIC
time-dependent killing
lowest concentration of antimicrobial that completely suppresses growth of an organism after an incubation of 18-24 hrs
minimum lethal concentration (MLC)
bacteria have __ ribosomes; mammalian cells have __ ribosomes
70S- bacterial cells
80S- mammalian cells
staph
gram pos cocci
strep pneumo
gram pos cocci
strep viridans
gram pos cocci
enteroccocus
gram pos cocci
bacillus
gram pos bacilli
cornyebacterium
gram pos bacilli
listeria monocytogenes
gram pos cocci aerobe
nocardia
gram pos cocci aerobe
acinetobacter
gram neg cocci aerobe
moraxella
gram negative cocci aerobe
neisseria
gram negative cocci aerobe
citrobacter
gram negative bacilli aerobe
enterobacter
gram negative bacilli aerobe
e. coli
gram negative bacilli aerobe
h. influenza
gram negative bacilli aerobe
helicobacter
gram negative bacilli aerobe
klebsiella
gram negative bacilli aerobe
proteus
gram negative bacilli aerobe
pseudomonas
gram negative bacilli aerobe
salmonella
gram negative bacilli aerobe
shigella
gram negative bacilli aerobe
borrelia
gram negative aerobe spirochete
treponema
gram negative aerobe spirochete
peptococcus
anaerobe above diaphragm
peptostreptococcus
anaerobe above diaphragm
prevatella
anaerobe above diaphragm
actinomyces
anaerobe above diaphragm
clostridium
anaerobe below diaphragm
bacteroides
anaerobe below diaphragm
fusobacterium
anaerobe below diaphragm

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