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Glossary of Biotech Test

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Daclizumab
(Zenapax)
-humanized monoclonal ab to IL-2R alpha
-prophylaxis of renal transplant rejection
-binds to IL-2 receptor on T-helper cells
Basiliximab
(Simulect)
-humanized monoclonal ab to IL-2R alpha
-renal, lier transplant rejection prophylaxis
-blocks binding of IL-2 to the IL-2R alpha subunit
Abciximab
(ReoPro)
-humanized Fab fragment that binds to glycoprotein IIb/IIIa receptor of platelets blocking aggregation
Infliximab
(Remicade)
-humanized monoclonal ab to TNF-alpha
I:Crohn's disease, RA
-binds and neuralizes TNF-alpha
Adalimumab
(HUMIRA)
-true human monoclonal to TNF-alpha
I:RA
-prefilled syringe w/plastic wings
Rituximab
(Rituxan)
-humanized monoclonal ab against CD-20
I:non-Hodgkin's lymphoma(relapsed or refractory),chronic lymhocytic leukemia, RA, macroglobulinemi, Walenstroms
-1st mab approved for cancer. CD20 is early signalling for cancer
Alemtuzumab
(Campath)
-humanized mab against CD-20
I:B-cell chronic lymphocytic leukemia
-watch CD4+ count
Efalizumab
(Raptiva)
-humanized mab against CD11a
I:plaque psoriasis (mod/severe)
-blocks binding to ICAM-1 required for cell commumication
Trastuzumab
(Herceptin)
-humanized mab against HER-2
I:breast cancer
-some pts have anaphylactic reactions
Cetuximab
(Erbitux)
-chimeric mab to EGFR
I:colorectral cancer,squamous cell cacinoma
-Martha's drug, requires +EGFR expression

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