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Glossary of Anthemintics

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Clorsulon
Inhibits glycolysis, used against blood and liver flukes
Diamphenithide
Inhibits glycolysis, used against blood and liver flukes
SALICYLANILIDES
Closantel
Proton ionophores, disrupt teguement of flukes, stop oxidative phosphorylation and uncouple proton gradient.
Bind to plama proteins
SUBSTITUTED PHENOLS
nitroxynil
Proton ionophores, disrupt teguement of flukes, stop oxidative phosphorylation and uncouple proton gradient.
Bind to plama proteins
BENZIMIDOLES
Thiabendazole
Bind to beta tubilin and inhibit microtublue polymerisation.
Stop mitosis and extretion, lower energy and allow host attack
Febantel -> Fenbendazole
Bind to beta tubilin and inhibit microtublue polymerisation.
Stop mitosis and extretion, lower energy and allow host attack
Praziquantel
Used against schistosomes, trematodes and flukes.
Absorbed and resecreted by Crypts of Lieberkuhn.
Increases calcium permeability, by binding to beta subunit of chanel. Cause spastic paralsis and teguement damage
Paraherquamide
Nicotinic receptor antagonist
Flaccid paralysis
AVERMECTINS
Ivermectin
Broad spectrum, increase glutmate gated chloride permeability. Flaccid paralysis of pharynx and egg laying.
NOT to give to collies, mdr-1 lacks PgP and crosses BBB
Milbemycins
Broad spectrum, increase glutmate gated chloride permeability. Flaccid paralysis of pharynx and egg laying.
NOT to give to collies, mdr-1 lacks PgP and crosses BBB
Piperazine
GABAn receptor agonist, causes hyperpolariseationa nd flaccid paralysis. Does not have carboxyl group, only works in gut where -COOH is mimicked.
Organophosphates
Covalent P bond AChE at esteric site.
Spastic Paralysis
CARBAMATES
Aldicarb
Carbamylate AChE
IMIDAZOTHIAZOLES
levamisole
nAChR agonist. Spastic paralysis and expulsion.
Soluble.
TETRAHYDROPYRIMIDINES
Pyrantel
nAChR agonist. Spastic paralysis and expulsion. Not soluble, give as oral

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