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Glossary of Alpha 2 Adrenergic agonists

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tx parkinson's
Methydopa
OH conjugation
decarboxylates
hydroxylates
methydopa
reaction occurs stereoselective
methydopa-it is hydroxylated only at one place and you get only 1 product (1R,2S) overall levo activity
better absorbed as a prodrug
methydopate
hydrolyzed in blood delayed
methydopate
duration is long
methydopate
generates no active metabolites
Reserpine
acts by indirect mechanism
Guanethedine
oxidative-deamination process
Guanethedine
metabolite is 10% as active as parent
Guanethedine
greater GI absorption than Guanethidine
Guanedrel

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