Glossary of Allosterism, Biology

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What is allosteric regulation?
molecules other than substrate that can bind to sites on enzyme s and activate or inactivate the enzyme.
What is end-product regulation?
The final product at the end of a metabolic pathway, feeds back and shuts off the first enzyme in the pathway
What changes conformation in an enzyme?
allosteric regulators
What does positive allosterism do?
binds regulatory molecule an increases enzyme activity (lower Km or higher Vmax)
What does negative allosterism do?
binds regulatory molecules to decrease enzyme activity (higher Km or lower Vmax)
How are possible mechanisms for enzyme inhibitors determined?
V vs [S] curves done in the presence of an inhibitor.
What do competitive inhibitors need to compete?
higher [S] , can obtain same Vmax with a higher Km
What happens to noncompetitive inhibitors Vmax? What about noncompetitive Km?
Vmax decreases however Km is unaffected.
Where do noncompetitive inhibitors bind?
sites other than the active (allosteric) site.
In noncompetitive inhibitors increase in [S] cannot do what?
overcome inhibition
What is the key regulatory step for glycolysis and the generation of ATP?
What are two allosteric activators?
AMP and ADP.

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