Glossary of Allosterism, Biology
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- What is allosteric regulation?
- molecules other than substrate that can bind to sites on enzyme s and activate or inactivate the enzyme.
- What is end-product regulation?
- The final product at the end of a metabolic pathway, feeds back and shuts off the first enzyme in the pathway
- What changes conformation in an enzyme?
- allosteric regulators
- What does positive allosterism do?
- binds regulatory molecule an increases enzyme activity (lower Km or higher Vmax)
- What does negative allosterism do?
- binds regulatory molecules to decrease enzyme activity (higher Km or lower Vmax)
- How are possible mechanisms for enzyme inhibitors determined?
- V vs [S] curves done in the presence of an inhibitor.
- What do competitive inhibitors need to compete?
- higher [S] , can obtain same Vmax with a higher Km
- What happens to noncompetitive inhibitors Vmax? What about noncompetitive Km?
- Vmax decreases however Km is unaffected.
- Where do noncompetitive inhibitors bind?
- sites other than the active (allosteric) site.
- In noncompetitive inhibitors increase in [S] cannot do what?
- overcome inhibition
- What is the key regulatory step for glycolysis and the generation of ATP?
- What are two allosteric activators?
- AMP and ADP.
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