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Glossary of Ag 412 GI Drugs

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Name an anti-ulcer drug?
Cimetidine (Tagament)
How does Cimetidine (Tagament) work?
decreases secretion of hydrochloric acid by blocking activation of H2 receptors
What are the clinical uses of Cimetidine (Tagament)?
*prevent gastric & duodenal uclers
*Tx of esophagitis
*Animals who are/have been vomiting
*Chronic renal failure patients
What are the other types of anti-ulcer drugs besides Cimetidine?
Ranitidine (Zantac)
Famotidine (Pepcid)
Name an antidiarrheal drug?
Diphenoxylate/Atropine (Lomotil)
What action does Diphenoxylate/Atropine (Lomotil) have?
increases segmental contractions which decrease the lumen resulting in slower passage of intestinal material
Why is Atropine added to Diphenoxylate (Lomotil)?
To prevent substance abuse
What is the clinical use of Diphenoxylate/Atropine (Lomotil)?
controls diarrhea
What other drug can be used as an antidiarrheal but does not have atropine?
Loperamide (Immodium)
Which drug is commonly used in dogs for antidiarrheal affects? Cats?
Dogs --> Diphenoxylate/Atropine (lomotil)
Cats --> Loperamide (Immodium)
Name a laxative drug used for animals?
Cisapride (Propulsid)
What action does Cisapride (Propulsid) have?
stimulates motility of the GI tract
What are the clinical uses of Cisapride (Propulsid)?
>Tx of constipation
>Megacolon (cats)
>GI stasis in rabbits
Name a antiemetic drug used in animals?
Metaclopramide (Reglan)
What action does Metaclopramide (Reglan) have?
>Speeds gastric emptying
>Increases cardiac sphincter tone
>Blocks pathway to vomiting center in brain
What are clinical uses of Metaclopramide (Reglan)?
>antiemetic
>motility disorders
What are the side effects of Metaclopramide (Reglan)?
>behavioral changes
>>hyperactivity - pant, pace, wine
>CNS disorders
>>ataxia, trembling, excessive panting, seizures
>constipation
Name a mucosal protectant drug?
Sucralfate (Carafate)
What are the clinical uses for Sucralfate (Carafate)?
>oral ulcers
>duodenal ulcers
>gastric ulcers
>esphagitis
>excessive vomiting
How does Sucralfate (Carafate) work?
binds to mucosal layer of stomach, when acid is produced there is a layer to protect lining of GI tract.
What are the side effects of Sucralfate (Carafate)?
>Constipation
>Don't want to feed and than give carafate - won't work
>>give carafate 1/2 hour before meal

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