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Glossary of ADRENAL HORMONE DRUGS

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Aminoglutethimide
inhibits synthesis of adrenal steroids
Fludrocortisone
promotes reabsorption of sodium and enhanced secretion of potassium, used for replacement therapy
Mineralocorticoids
involved w/Na fluid balance
HOW ARE CORTICOSTEROIDS CLASSIFIED?
classified as short, intermediate or long acting
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HOW DO CORTICOSTERIODS DIFFER?
IN POTENCY, ONSET & DURATION
WHAT CLASSIFICATION OF DRUG IS PREDNISONE?
INTERMEDIATE ACTING
WHAT IS PREDNISONE USED FOR?
replacement therapy (adrenal insufficiency
rheumatic disorders
renal disease
allergic disease
asthma
infectious disease
skin disease
GI disease
hepatic disease
Pharmacologic Actions of Glucocorticoids?
Anti-inflammatory action
Maintenance of normal blood pressure
Carbohydrate and protein metabolism
Fat metabolism
Thymolytic, lympholytic, and eosinopenic actions
Stress effects
Central nervous system
Methimazole
inhibit incorporation of iodide during the process of T3/T4 synthesis
Antithyroid Agents
Levothyroxine: synthetic T3


Iodine: high concentrations decrease the synthesis of T3 and T4

Radioactive Iodide: particle emissions destroys tissue, used for hyperthyroidism
how were tyroid preparations initially derived?
pigs & cow
Bisphosphonates
inhibit bone resorption, Paget's Disease (abnormal bone growth) used for hyperparathyroid hormone levels
Calcitonin
remember important for calcium uptake to bone
Parathyroid
remember PTH decreases body calcium
what does the parthyroid decrease in the body?
calcium
Vasopressin
aka ADH, used to treat diabetes insipidus, extreme polyuria, deficiency of ADH
Octreotide (Sandostatin)
somatostatin analog, inhibits GH, used to treat GH excess
Somatropin (various trade names)
identical to GH, same indication
Somatrem (Protropin)
derivative of GH, used to treat GH deficiency
what 4 types of cells does the islets of lanagerhans contain?
islets of langerhans contain several types of cells:
alpha: secrete glucagon, stimulates production of glucose
in the liver
beta: secrete insulin, number of actions including uptake
of glucose by various tissues
delta: secrete somatostatin, reduce absorption of food
gamma: peptide with unknown function

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