Glossary of 8. Viral Hepatitis
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- What's the incubation period of:
- A = 2-6 wks
E = 3-6 wks
D = 3-13 wks
B = 8-24 wks
C = 2-52 wks
- Which hepatitis have onset thats
- Acute = A, E, D.
Insidious = B, C.
- How are Hepatitis A and E transmitted?
- How are Hepatitis B, C, and D transmitted?
- Which hepatitis types exhibit chronic states?
- B, C, and D.
- How would you diagnose Hepatitis due to alcoholic cirrhosis?
- AST high
- For which hepatitis viruses do immunizations exhist?
- -Hep A
- What food is Hep A esp. associated with?
- What 2 antibodies are used as serologic markers of HAV?
- 1. Total Anti-HAV
2. IgM anti-HAV
- what does Total Anti-HAV indicate?
- Immune status; it's a life-longer marker.
-Does NOT distinguish acute from past infection
- What does IgM Anti-HAV indicate?
- Acute disease.Remains 6 months.
- What are the normal serologic markers on an Acute Viral Hepatitis panel?
- 1. IgM Anti-HAV
3. IgM Anti-HBc
- What's another name for Hep B?
- Serum hepatitis
- What is the danger of dying from hepatitis B in babies that recieve it perinatally?
- Low; but 95% chance of being a carrier.
- What shot is given to babies in case of Hep B transmisison?
- what is H-BIG?
- Anti-hepatitis B immunoglobulin; a passive antibody for immediate resistance to the organism.
- Who is at increased risk of developing chronic hep B?
- children under the age of 5.
- What is the 1st marker in Hep B?
When does it disappear?
What does it infer?
-Gone with symptoms clearing
- Which marker indicates ACUTE Hep B infeciton?
- Anti-HepB core IgM
- when does IgM Anti-HBc rise and fall?
- -Rises soon after HBsAg; falls soon after HbSAg, but TOTAL stays high.
- Which Hep B marker infers recovery and immunity?
-When does it appear?
- Anti-HBs; rises during convalescence.
- When does anti-HBe begin to replace HBe-Ag?
- When symptoms begin to disappear
- What can evaluating HBeAg and Anti-HBe levels do for evaluation of hepatitis B?
- Signal chronic infection; the antigen will remain for months to years, instead of only weeks.
- What 2 markers indicate chronic Hep B infections?
- -HBeAg present way too long
-HBsAg remains elevated instead of disappearing with symptoms.
-NO ANTI-HBS APPEARS
- what are 2 types of chronic HB?
What is the difference btwn them
- Chronic active
-Active does not seroconvert HBeAg to antibody.
- What are the 2 types of Hep D infection?
- -Co-infection with Hep B
- What is the deal with Hep D superinfection?
- -Occurs AFTER Hep B infection.
-Usually becomes chronic
-Hi risk severe chronic liver disease.
- What markers can we detect for Hep D in the lab?
- Anti-HDV Total
- what marker is useful in detecting hepatitis C?
- how do we differentiate chronic infections from acute?
- Acute - normal ALT peak/decline
Chronic - crazy ALT levels
- What is significant to remeber re: Anti-HCV?
- it is not protective.
- What 3 methods are used for supplemental testing for HC after the serological screen?
- -Recombinant immunoblot assay
-HCV RNA with PCR
-Reverse Transcription PCR
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