Glossary of 2b. ANA testing
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- Homogenous ANA pattern is highly suggestive of:
- Which antibodies cause a positive homogenous pattern?
- Antigens detected in a homogenous pattern are:
- dsDNA, ssDNA, nDNA, DNA, and
- Rim ANA pattern is highly suggestive of:
- Which antibodies cause a RIM pattern?
- Which cells exhibit the rim pattern, mitotic or non?
- Antigens detected in a rim pattern are:
- same as in homogenous; dsDNA, ssDNA, nDNA, DNA, and histone.
- What is the most common ANA pattern?
- What are high titers of speckled ANA cells suggestive of?
- SLE, Scleroderma, Sjogren's, and MCTD.
- Antigens detected in a SPECKLED pattern are:
- Sm, RNP, Scl-70, and SS-B.
- What is the least common ANA pattern?
- How do nucleolar cells look?
- Mitotic - negative
Nonmitotic - only nucleoli flouresce.
- A high titer of nucleolar staining is suggestive of:
- Antigens detected in a NUCLEOLAR pattern are:
- 4-6s and RNA
- After getting a pos ANA of a particular pattern, what is the next step?
- Do specific testing based on which pattern is observed.
- What patterns could be observed for SLE?
- -Homogenous (most likely)
- what are specific tests for SLE?
- 1. Anti-native DNA (dsDNA)
- What methodology can be used for all specific autoab testing?
- What additional methods can be used for SLE-spcf testing?
- What is a specific test for MCTD?
- Anti-RNP in HIGH titers.
Methods are IDA, Elisa/EIA.
- What are specific tests for Sjogren's Syndrome?
- 1. Anti-SS-A
- What is a specific test for drug-induced SLE?
- Anti-histone by IDA/ELISA/EIA.
- What is a specific test for Scleroderma?
- Anti-Scl-70 by IDA/Elisa/EIA.
- What test is specific for Myositis?
- Anti-Jo-1 by IDA/Elisa/EIA.
- What test is specific for RA?
- Rheumatoid FACTOR (rf) by Latex agglutination, Nephelometry, and Elisa/EIA of course.
- What isotype antibody is RF?
- Usually IgM (but can be IgG)
- What is the RF antibody against?
- Anti-Fc portion of IgG/
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