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Glossary of 1st AID USMLE Step 1 hematology physiology

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Factor XII

Intrinsic, extrinsic or common?
intrinsic
Factor XII

PTT or PT?
PTT
Factor XII

activates?
XI
Factor XI

Intrinsic, extrinsic, or common?
Intrinsic
Factor XI

PTT or PT?
PTT
Factor XI

activates?
IX

***requires Ca++ and platelet phospholipid
Factor IX

Intrinsic, extrinsic, or common?
intrinsic
Factor IX

PTT or PT
PTT
Factor IX

activates?
X
**requires Ca++ and platelet phospholipid
Factor VII

intrinsic, extrinsic, or common?
extrinsic
Factor VII

PTT or PT?
PT
Factor VIIa

Activates?
X
**requires Ca++ and platelet phospholipid
Tissue factor

activates?
VII

**requires Ca++ and platelet phospholipid
Xa and Va

Activate?
Prothrombin

**requires Ca++ and platelet phospholipid
factor X

intrinsic, extrinsic, or common?
common
Thrombin

activates?
Fibrinogen
Factor which crosslinks fibrin
XIIIa
inactivate Va and VIIIa
Protein C
Protein S
**Vitamin K dependent
inactivates:
thrombin
IXa
Xa
XIa
Antithrombin III
activated by heparin
Antithrombin III
generates plasmin, which cleaves fibrin
tPA
fibrinolytic system link to complement cascade?
plasminogen activates C3
Clotting link to kallikrein-kinin system
XIIa activates Prekallikrein
->kallikrein
Kallikrein link to kinin system?
kallikrein activates HMWK
-->Bradykinin
Kallikrein link to fibrinolytic system
Kallikrein activates Plasminogen
-->Plasmin
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